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Titolo:
Chronic cold stress reduces the spontaneous activity of ventral tegmental dopamine neurons
Autore:
Moore, H; Rose, HJ; Grace, AA;
Indirizzi:
Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 eurosci, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 sychiat, Pittsburgh, PA 15260 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 24, anno: 2001,
pagine: 410 - 419
SICI:
0893-133X(200104)24:4<410:CCSRTS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; TYROSINE-HYDROXYLASE ACTIVITY; NUCLEUS-ACCUMBENS; SUBSTANTIA-NIGRA; NOREPINEPHRINE RELEASE; SELECTIVE ACTIVATION; LOCUS COERULEUS; FRONTAL-CORTEX; ANIMAL-MODEL; RAT-BRAIN;
Keywords:
ventral tegmental area; nucleus accumbens; prefrontal cortex; dopamine neurons; stress; dopamine release;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Moore, H Univ Pittsburgh, Dept Neurosci, 446 Crawford Hall, Pittsburgh, PA15260 USA Univ Pittsburgh 446 Crawford Hall Pittsburgh PA USA 15260 260 USA
Citazione:
H. Moore et al., "Chronic cold stress reduces the spontaneous activity of ventral tegmental dopamine neurons", NEUROPSYCH, 24(4), 2001, pp. 410-419

Abstract

The dopamine (DA) neurons in the ventral tegmental area and medial substantia nigra (VTA/mSN) projecting to the limbic forebrain and prefrontal cortex have long been postulated to play a major role in cognitive and behavioral effects of stress. In this study, the effects of a chronic stressor (prolonged exposure to cold) on the spontaneous activity of DA neurons in the VTA/mSN were examined. Extracellular single-unit recordings of DA neurons were e performed in rats following a 17-day continuous exposure to a cold (4 degreesC) environment. Compared to controls, cold-exposed rats displayed 64%fewer spontaneously active DA neurons. The average spike activity (averagefiring rate, average spikes fixed it bursts) oft he DA cells that remainedactive in the cold-exposed mts did not differ significantly from controls. However, a significantly larger proportion of those cells showed excessiveburst activity, compared to the DA cell population in controls. These results show that chronic stress can lead to the cessation of spontaneous activity ill a subpopulation of VTA/mSN DA cells. These changes may indicate that unlike acute stress, which call potently activate the mesolimbic/mesocortical DA systems, chronic stress leads to ail adaptive reduction in the number of active DA cells, perhaps altering the response of these systems to subsequent stressors. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 25/01/20 alle ore 19:02:38