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Titolo:
Reduced brain serotonin activity disrupts prepulse inhibition of the acoustic startle reflex: Effects of 5,7-dihydroxytryptamine and p-chlorophenylalanine
Autore:
Fletcher, PJ; Selhi, ZF; Azampanah, A; Sills, TL;
Indirizzi:
Ctr Addict & Mental Hlth, Sect Biopsychol, Clarke Div, Toronto, ON M5T 1R8, Canada Ctr Addict & Mental Hlth Toronto ON Canada M5T 1R8 to, ON M5T 1R8, Canada Univ Toronto, Dept Psychiat, Toronto, ON, Canada Univ Toronto Toronto ON Canada ronto, Dept Psychiat, Toronto, ON, Canada Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada Univ Toronto Toronto ON Canada M5S 1A1 ychol, Toronto, ON M5S 1A1, Canada
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 24, anno: 2001,
pagine: 399 - 409
SICI:
0893-133X(200104)24:4<399:RBSADP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT1A RECEPTOR AGONIST; RAT-BRAIN; WISTAR RATS; HABITUATION; MODULATION; 8-OH-DPAT; NEURONS; DORSAL; SCHIZOPHRENIA; LOCALIZATION;
Keywords:
prepulse inhibition; startle reflex; serotonin; 5,7-dihydroxytryptamine; 8-OH-DPAT; p-chlorophenylalanine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Fletcher, PJ Ctr Addict & Mental Hlth, Sect Biopsychol, Clarke Div, 250 Coll St, Toronto, ON M5T 1R8, Canada Ctr Addict & Mental Hlth 250 Coll St Toronto ON Canada M5T 1R8
Citazione:
P.J. Fletcher et al., "Reduced brain serotonin activity disrupts prepulse inhibition of the acoustic startle reflex: Effects of 5,7-dihydroxytryptamine and p-chlorophenylalanine", NEUROPSYCH, 24(4), 2001, pp. 399-409

Abstract

These experiments examined the impact of extensive depletions of forebrain53-hydroxytryptamine (5-HT; serotonin) levels on prepulse inhibition (PPI)of the acoustic startle reflex in rats. In Experiment 1 injection of the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) into the dorsal and median raphe nuclei disrupted PPI. This deficit was observed beginning 2 clays after lesioning and was still apparent 8 weeks later. Basal startle reactivity wasnot altered. The 5-HT1A receptor agonist 8-OH-DPAT (0.1 mg/ kg) and the dopamine receptor agonist apomorphine (1mg/ kg) also disrupted PPI; the effect of 8-OH-DPAT, but not opomorphine, was potentaiated in 5-HT-depleted rats. Basal startle reactivity was enhanced by 8-OH-DPAT in sham-lesioned rats brit not in 5,7-DHT-lesioned rats. In Experiment 2, a second method for depleting 5-HT was used. The tryptophan hydroxylase inhibitor p-chlorophenylalanine (PCPA) also disrupted PPI without altering basal startle reactivity. Again, 8-OH-DPAT disrupted PPI in control animals; this effect was not altered in PCPA-treated also but the increase in basal startle reactivity induced by 8-OH-DPAT tons not observed in PCPA-treated rats. Taken together withthe results of previous experiments involving drugs that enhance 5-HT neurotranssmission it appears that both increases and decreases in 5-HT activity disrupt PPI. (C) 2001 American College of Neuropsychopharmacology Published by Elsevier Science Inc.

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Documento generato il 21/01/20 alle ore 00:57:30