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Titolo:
Idazoxan and 8-OH-DPAT modify the behavioral effects induced by either NA,or 5-HT, or dual NA/5-HT reuptake inhibition in the rat forced swimming test
Autore:
Reneric, JP; Bouvard, M; Stinus, L;
Indirizzi:
Univ Bordeaux 2, CNRS UMR 5541, Lab Neuropsychobiol Desadaptat, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 daptat, F-33076 Bordeaux, France Univ Bordeaux 2, Serv Psychiat Enfant & Adolescent, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 escent, F-33076 Bordeaux, France
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 24, anno: 2001,
pagine: 379 - 390
SICI:
0893-133X(200104)24:4<379:IA8MTB>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; NUCLEUS-RAPHE-DORSALIS; MAJOR DEPRESSION; ANTIDEPRESSANT TREATMENTS; DOUBLE-BLIND; ENDOGENOUS NORADRENALINE; BUSPIRONE AUGMENTATION; RESISTANT DEPRESSION; RECEPTOR AGONIST; SEROTONIN;
Keywords:
antidepressants; forced swimming; serotonin; noradrenaline; interactions desipramine; fluoxetine; milnacipran; idazoxan; 8-OH-DPAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Reneric, JP Univ Bordeaux, Dept Psychiat Enfant & Adolescent, CHS Ch Perrens, 121 Rue Bechade, F-33076 Bordeaux, France Univ Bordeaux 121 Rue BechadeBordeaux France F-33076 France
Citazione:
J.P. Reneric et al., "Idazoxan and 8-OH-DPAT modify the behavioral effects induced by either NA,or 5-HT, or dual NA/5-HT reuptake inhibition in the rat forced swimming test", NEUROPSYCH, 24(4), 2001, pp. 379-390

Abstract

The rat forced swimming test (FST) predicts the efficacy of antidepressants, which decrease immobility duration in the test, and can distinguish selective serotonin (5-HT) and noradrenanline (NA) reuptake inhibitors, which, respectively, increase swimming and climbing behaviors. However, dual 5-HT and NA reuptake-inhibition produces climbing behavior solely, thereby suggesting with others data that the NA-system mediates inhibiting interactions on 5-HT-induced swimming in the FST. Since alpha (2)-adrenoreceptors and 5-HT1A-receptors have important regulatory functions and are involved ill 5-HT/NA interactions, we examined whether the alpha (2)-receptor-antagonist idazoxan and the 5-HT1A-receptor-agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) would modify the behavioral pattern induced in the FST by either selective or non-selective antidepressant treatments. The rats were treated subacutely (3 injections IP over 48 h) with: (a) idazoxan (0.5-10 mg/kg) alone, and in combination with desipramine (10 mg/kg), or desipramine floxetine (10/10 mg/kg), or the dual serotonin/ noradrenaline reuptake-inhibitor milnacipran (20 mg/kg). (bi 8-OH-DPAT(0.25-1 mg/kg) alone, and in combination with either desipramine (10 mg/kg) or fluoxetine (10 mg/kg kg). The results indicated: (a) Idazoxan (0.5, 5, 10 mg/kg) produced no anti-immobility effects per se in the FST, antagonized the effects of the NA-reuptake-inhibitor desipramine, and allowed desipramine + fluoxetine, as well as milnacipran, to increase swimming behavior. (b) 8-OH-DPAT produced non-significant effects per se, potentiated desipramine-induced antidepressant-like effects on immobility and climbing, and both antagonized swimming and produced climbing behavior in combination with fluoxetine. Our data support clinical trials suggesting that alpha (2)-receptor-antagonists and 5-HT1A-receptor-agonists may be of interest in augmentation strategies for antidepressant treatments. The scoring of active behaviors in the FST appears to be an interesting tool for studying 5-HT/NA interactions induced by antidepressants, as well as for the testing of augmentation strategies. (C) 2001 AmericanCollege of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 22/01/20 alle ore 06:31:15