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Titolo:
Social impulsivity inversely associated with CSF5-HIAA and fluoxetine exposure in vervet monkeys
Autore:
Fairbanks, LA; Melega, WP; Jorgensen, MJ; Kaplan, JR; McGuire, MT;
Indirizzi:
Univ Calif Los Angeles, Inst Neuropsychiat, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Wake Forest Univ, Sch Med, Dept Pathol Comparat Med, Winston Salem, NC 27109 USA Wake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA Vet Adm Med Ctr, Dept Psychiat, Sepulveda, CA 91343 USA Vet Adm Med Ctr Sepulveda CA USA 91343 Psychiat, Sepulveda, CA 91343 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 24, anno: 2001,
pagine: 370 - 378
SICI:
0893-133X(200104)24:4<370:SIIAWC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGGRESSIVE-BEHAVIOR; NONHUMAN-PRIMATES; SEROTONIN FUNCTION; PERSONALITY; 5-HIAA; METABOLITES; PAROXETINE; VOLUNTEERS; CORRELATE; DISORDER;
Keywords:
impulsivity; aggression; serotonin; 5-hydroxyindoleacetic acid (5-HIAA); fluoxetine; primate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Fairbanks, LA Univ Calif Los Angeles, Inst Neuropsychiat, Dept Psychiat & Biobehav Sci, 760 Westwood Plaza, Los Angeles, CA 90024 USA Univ Calif Los Angeles 760 Westwood Plaza Los Angeles CA USA 90024
Citazione:
L.A. Fairbanks et al., "Social impulsivity inversely associated with CSF5-HIAA and fluoxetine exposure in vervet monkeys", NEUROPSYCH, 24(4), 2001, pp. 370-378

Abstract

Animal and humnn research suggests that the central serotonin system is involved in the inhibition of impulsive behavior. Two studies were designed to assess this relationship in male vervet monkeys (Cercopithecus aethiops sabaeus) rising a standardized test of impulsivity in a social context: the Intruder Challenge. In the first study an inner of impulsivity in response to an unfamiliar adult male intruder (including latency to approach and aggressive and assertive interactions) was inversely correlated With levels ofthe serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA) in cisternalcerebrospinal fluid (r = -0.33, p < .01, n = 138). The approach, but not aggressive, component of the Impulsivity Index runs the primary contributor to this relationship (partial r = -0.27, p < .01). The second experiment compared responses to the Intruder Challenger after 9 weeks of daily treatment with fluoxetine (2 mg/kg, i.m.) or vehicle. Fluoxetine-treated subjects (n = 6) had significantly lower Impulsivity Index scores than controls (n = 12). The results from these two investigations provide evidence for serotonergic influences on social impulsivity. (C) 2001 American College of Neuropsychopharmocology. Published by Elsevier Science Inc.

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Documento generato il 25/01/20 alle ore 18:30:13