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Titolo:
The effects of transdermal nicotine therapy for smoking cessation on depressive symptoms in patients with major depression
Autore:
Thorsteinsson, HS; Gillin, JC; Patten, CA; Golshan, S; Sutton, LD; Drummond, S; Clark, CP; Kelsoe, J; Rapaport, M;
Indirizzi:
UCSD, VAMC 116A, Psychiat Serv, San Diego, CA 92161 USA UCSD San Diego CAUSA 92161 116A, Psychiat Serv, San Diego, CA 92161 USA Univ Calif San Diego, Joint Doctoral Program Clin Psychol, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 chol, San Diego, CA 92103 USA Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 hiat, San Diego, CA 92103 USA San Diego Healthcare Syst, Vet Adm, Psychiat Serv, San Diego, CA USA San Diego Healthcare Syst San Diego CA USA chiat Serv, San Diego, CA USA Mayo Clin, Dept Psychol, Rochester, MN USA Mayo Clin Rochester MN USAMayo Clin, Dept Psychol, Rochester, MN USA Mayo Clin, Nicotine Res Ctr, Rochester, MN USA Mayo Clin Rochester MN USA ayo Clin, Nicotine Res Ctr, Rochester, MN USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 24, anno: 2001,
pagine: 350 - 358
SICI:
0893-133X(200104)24:4<350:TEOTNT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENCE; SMOKERS; COMORBIDITY; CLONIDINE; ADULTS; TRIALS; WOMEN; SLEEP; MOOD;
Keywords:
depressive disorder; smoking cessation; nicotine; withdrawal symptoms; randomized clinical trial;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Gillin, JC UCSD, VAMC 116A, Psychiat Serv, 3350 La Jolla Village Dr, San Diego, CA 92161 USA UCSD 3350 La Jolla Village Dr San Diego CA USA 92161 92161 USA
Citazione:
H.S. Thorsteinsson et al., "The effects of transdermal nicotine therapy for smoking cessation on depressive symptoms in patients with major depression", NEUROPSYCH, 24(4), 2001, pp. 350-358

Abstract

This study examines the effects of transdermal nicotine patches for smoking cessation on depressive and withdrawal symptoms among 38 non-medicated subjects with Major Depressive Disorder. The study was conducted over a 29-day period, which included a 7 day baseline phase, a 14 day treatment phase, and an 8 day placebo phase. During the treatment phase subjects received either active nicotine patches (N = 18) or placebo patches (N = 20) that wereadministered in a randomized, double-blind fashion. The target quit date (TQD) was day 8. Significantly, more subjects in the placebo group than in the nicotine group resumed smoking following the TQD (50% vs. 22%). There was little evidience for effects of active nicotine patches oil measures of mood (HRSD, BDI, POMS) or withdrawal symptoms among subjects that remained abstinent throughout the study (N = 24). Those who resumed smoking had more severe withdrwal symptoms than those who remained abstinent. One patient inthe placebo group (n = 20) became more depressed after 2 weeks of abstinence None of the patients in the nicotine group (n = 18) became move depressed. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 29/03/20 alle ore 01:58:58