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Titolo:
Multiple 5-HT1 autoreceptor subtypes govern serotonin release in dorsal and median raphe nuclei
Autore:
Hopwood, SE; Stamford, JA;
Indirizzi:
Royal London Hosp, St Bartholomews & Royal London Sch Med & Dent, Acad Dept Anaesthesia & Intens Care, Neurotransmiss Lab, London E1 1BB, England Royal London Hosp London England E1 1BB miss Lab, London E1 1BB, England
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 4, volume: 40, anno: 2001,
pagine: 508 - 519
SICI:
0028-3908(200103)40:4<508:M5ASGS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAST CYCLIC VOLTAMMETRY; RECEPTOR MESSENGER-RNA; RAT-BRAIN; BINDING-SITES; EXTRACELLULAR 5-HYDROXYTRYPTAMINE; CHRONIC PAROXETINE; ADULT-RAT; NEURONS; LOCALIZATION; HIPPOCAMPUS;
Keywords:
5-HT1A; 5-HT1B; 5-HT1D; autoreceptor; dorsal raphe nucleus; median raphe nucleus; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Stamford, JA Royal London Hosp, St Bartholomews & Royal London Sch Med & Dent, Acad Dept Anaesthesia & Intens Care, Neurotransmiss Lab, Alexandra Wing, London E1 1BB, England Royal London Hosp Alexandra Wing London England E1 1BB gland
Citazione:
S.E. Hopwood e J.A. Stamford, "Multiple 5-HT1 autoreceptor subtypes govern serotonin release in dorsal and median raphe nuclei", NEUROPHARM, 40(4), 2001, pp. 508-519

Abstract

The present study investigated the possibility of multiple 5-HT1 autoreceptor subtypes in the rostral raphe nuclei. Slices (350 mum) of rat dorsal ormedian raphe nucleus (DRN/MRN) were taken from male Wistar rats and superfused with artificial cerebrospinal fluid at 32 degreesC. Fast cyclic voltammetry at carbon fibre microelectrodes was used to monitor serotonin (5-HT) release following local electrical stimulation. In both DRN and MRN, 5-HT release on short trains was reduced by the selective 5-HT1A agonist 8-OH-DPAT (1 muM), an effect blocked by the selective 5-HT1A antagonist WAY 100635 (0.1 muM) but not by SB 216641 (0.05 and 0.2 muM) or BRL 15572 (0.5 muM), selective antagonists at the 5-HT1B and 5-HT1D receptors respectively. The selective 5-HT1B agonist CP 93129 (0.3 muM) also reduced 5-HT release in both nuclei. Its effect was blocked by SB 216641 but not by WAY 100635 or BRL 15572. The 5-HT1D/1B agonist sumatriptan (0.5 muM) decreased 5-HT release in both DRN and MRN. In DRN, the effect of sumatriptan was blocked by BRL 15572 but not by WAY 100635 or SB 216641. In MRN, the effect of sumatriptan was not blocked by any of the above antagonists. BRL 15572 increased 5-HT release on long stimulations in DRN and MRN while WAY 100635 had no effect. SB 216641 increased 5-HT release in MRN but not DRN. WAY 100635 potentiated the effect of SB 216641 in DRN but not MRN. The data suggest that 5-HT release in DRN is controlled by 5-HT1A, 5-HT1B and 5-HT1D autoreceptors. 5-HT release in MRN is controlled by 5-HT1A and 5-HT1B autoreceptors and another,as yet unidentified mechanism. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 10:14:46