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Titolo:
Interferon-gamma release in sympathetically denervated rat submaxillary lymph nodes
Autore:
Castrillon, PO; Cardinali, DP; Arce, A; Cutrera, RA; Esquifino, AI;
Indirizzi:
Univ Buenos Aires, Fac Med, Dept Fisiol, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1121 Aires, DF, Argentina Univ Complutense Madrid, Fac Med, Dept Bioquim & Biol Mol 3, Madrid, SpainUniv Complutense Madrid Madrid Spain ioquim & Biol Mol 3, Madrid, Spain
Titolo Testata:
NEUROIMMUNOMODULATION
fascicolo: 4, volume: 8, anno: 2000,
pagine: 197 - 202
SICI:
1021-7401(2000)8:4<197:IRISDR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORNITHINE DECARBOXYLASE ACTIVITY; AUTONOMIC NERVOUS-SYSTEM; IMMUNE-SYSTEM; CHEMICAL SYMPATHECTOMY; MITOGENIC RESPONSES; T-CELL; LIPOPOLYSACCHARIDE; PROLIFERATION; CYCLOSPORINE; MODULATION;
Keywords:
interferon-gamma release; mitogenic responses; submaxillary lymph nodes; superior cervical ganglion; sympathetic nerves; norepinephrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Cardinali, DP Univ Buenos Aires, Fac Med, Dept Fisiol, Paraguay 2155, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Paraguay 2155 Buenos Aires DF Argentina RA-1121
Citazione:
P.O. Castrillon et al., "Interferon-gamma release in sympathetically denervated rat submaxillary lymph nodes", NEUROIMMUNO, 8(4), 2000, pp. 197-202

Abstract

Objective: To examine the regulation of interferon (IFN)-gamma release by cells derived from submaxillary lymph nodes of rats subjected to an acute or chronic superior cervical ganglionectomy (SCGx). Methods: A unilateral SCGx and a contralateral sham operation were performed. Twenty hours or 7 days later cells from submaxillary lymph nodes were incubated for 24 h withoutany additional treatment (experiment 1), after adding lipopolysaccharide or concanavalin A (experiment 2) or after adding norepinephrine (NE, 10(-8) M; experiment 3). IFN-gamma concentration in the culture media was measuredby ELISA. Results: Compared to controls, cells obtained from lymph nodes at a time of degeneration of sympathetic nerve terminals released more IFN-gamma, whereas those derived from chronically SCGx lymph nodes released lessIFN-gamma. Stimulation of IFN-gamma release by mitogens was detectable in the innervated or acutely denervated lymph nodes, but not in chronically denervated lymph nodes. When the effect of 10(-8) M NE on IFN-gamma release was tested, the neurotransmitter augmented cytokine release in cells prepared from chronically denervated lymph nodes only. Conclusion: The microenvironment provided by local sympathetic nerves is essential to enable an appropriate IFN-gamma release by submaxillary lymph node cells to occur. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 18/01/21 alle ore 16:29:12