Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Voxel-based morphometry of herpes simplex encephalitis
Autore:
Gitelman, DR; Ashburner, J; Friston, KJ; Tyler, LK; Price, CJ;
Indirizzi:
Northwestern Univ, Dept Neurol, Cognit Neurol & Alzheimers Dis Ctr, Chicago VA Healthcare Syst,Lakeside Div, Chicago, IL 60611 USA Northwestern UnivChicago IL USA 60611 akeside Div, Chicago, IL 60611 USA Northwestern Univ, Dept Radiol, Cognit Neurol & Alzheimers Dis Ctr, Chicago VA Healthcare Syst,Lakeside Div, Chicago, IL 60611 USA Northwestern UnivChicago IL USA 60611 akeside Div, Chicago, IL 60611 USA Univ Coll London, Functional Imaging Lab, London, England Univ Coll London London England Functional Imaging Lab, London, England Univ Cambridge, Dept Expt Psychol, Cambridge, England Univ Cambridge Cambridge England Dept Expt Psychol, Cambridge, England
Titolo Testata:
NEUROIMAGE
fascicolo: 4, volume: 13, anno: 2001,
pagine: 623 - 631
SICI:
1053-8119(200104)13:4<623:VMOHSE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROBABILISTIC ATLAS; BRAIN MORPHOMETRY; MRI; NEUROANATOMY; MATTER; GRAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Gitelman, DR Northwestern Univ, Dept Neurol, Cognit Neurol & Alzheimers Dis Ctr, Chicago VA Healthcare Syst,Lakeside Div, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Chicago, IL 60611 USA
Citazione:
D.R. Gitelman et al., "Voxel-based morphometry of herpes simplex encephalitis", NEUROIMAGE, 13(4), 2001, pp. 623-631

Abstract

Voxel-based morphometry (VBM) is a powerful tool for analyzing changes in gray or white matter density of the brain. By using an automated segmentation procedure and standardized parametric statistics it avoids biases inherent in operator-dependent morphological operations (J. Ashburner and K. J. Friston, 2000, NeuroImage 11, 805-821), Since its introduction in 1995, VERIhas been used to examine anatomical changes in a variety of diseases associated with neurologic and psychiatric dysfunction. Given the power of this technique for discerning subtle anatomical changes, we wanted to assess itsperformance on brains with gross structural abnormalities. Such results could have implications regarding the difficulties to be faced when examiningother types of distorted brains (e.g., brains with changes due to degenerative disease). This report describes the use of VBM for examining individual and group changes in gray matter concentration in five patients who had recovered from herpes simplex encephalitis (HSE) compared with age- and sex-matched controls. Because HSE tends to affect a specific set of brain regions we thought that this would (1) provide an opportunity to assess the anatomical face validity of VBM, (2) allow us to assess the problems of this technique when used on distorted brains, and (3) provide an in vivo demonstration of the gray matter changes due to HSE. We found that, despite problemsin normalizing and segmenting these severely distorted brains, VBM was able to identify correctly a number of the regional gray matter abnormalities in HSE. The results, while consistent with the well-known histopathology ofthe disease, also demonstrate potential difficulties with this method. (C)2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:09:46