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Titolo:
Protein thiol oxidation by haloperidol results in inhibition of mitochondrial complex I in brain regions: comparison with atypical antipsychotics
Autore:
Balijepalli, S; Kenchappa, RS; Boyd, MR; Ravindranath, V;
Indirizzi:
Natl Inst Mental Hlth & Neurosci, Dept Neurochem, Bangalore 560029, Karnataka, India Natl Inst Mental Hlth & Neurosci Bangalore Karnataka India 560029 , India NCI, Frederick Canc Res & Dev Ctr, Dev Therapeut Program, Lab Drug Discovery Res & Dev, Frederick, MD 21702 USA NCI Frederick MD USA 21702 g Discovery Res & Dev, Frederick, MD 21702 USA Natl Brain Res Ctr, New Delhi 110067, India Natl Brain Res Ctr New DelhiIndia 110067 s Ctr, New Delhi 110067, India
Titolo Testata:
NEUROCHEMISTRY INTERNATIONAL
fascicolo: 5, volume: 38, anno: 2001,
pagine: 425 - 435
SICI:
0197-0186(200104)38:5<425:PTOBHR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-TRANSPORT CHAIN; LIPOIC ACID; PARKINSONS-DISEASE; CEREBRAL-ISCHEMIA; GLUTATHIONE; DOPAMINE; STRESS; RATS; REPERFUSION; RECEPTORS;
Keywords:
antipsychotic; haloperidol; brain; complex I; mitochondria; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Ravindranath, V Natl Inst Mental Hlth & Neurosci, Dept Neurochem, Hosur Rd, Bangalore 560029, Karnataka, India Natl Inst Mental Hlth & Neurosci HosurRd Bangalore Karnataka India 560029
Citazione:
S. Balijepalli et al., "Protein thiol oxidation by haloperidol results in inhibition of mitochondrial complex I in brain regions: comparison with atypical antipsychotics", NEUROCHEM I, 38(5), 2001, pp. 425-435

Abstract

Usage of 'typical' but not 'atypical' antipsychotic drugs is associated with severe side effects involving extrapyramidal tract (EPT). Single dose ofhaloperidol caused selective inhibition of complex I in frontal cortex, striatum and midbrain (41 and 26%, respectively) which was abolished by pretreatment of mice with thiol antioxidants, alpha -lipoic acid and glutathioneisopropyl ester: and reversed, in vitro, by disulfide reductant, dithiothreitol. Prolonged administration of haloperidol to mice resulted in complex I loss in frontal cortex, hippocampus, striatum and midbrain, while chronicdosing with clozapine affected only hippocampus and frontal cortex. Risperidone caused complex I loss in frontal cortex, hippocampus and striatum butnot in midbrain from which extrapyramidal tract emanates. Inhibition of the electron transport chain component, complex I by haloperidol is mediated through oxidation of essential thiol groups to disulfides, in vivo. Further, loss of complex I in extrapyramidal brain regions by anti-psychotics correlated with their known propensity to generate side-effects involving extra-pyramidal tract. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:09:32