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Titolo:
Effect of PD fluid instillation on the peritonitis-induced influx and bacterial clearing capacity of peritoneal cells
Autore:
Hekking, LHP; Huijsmans, A; Van Gelderop, E; Wieslander, AP; Havenith, CEG; van den Born, J; Beelen, RHJ;
Indirizzi:
Free Univ Amsterdam, Fac Med, Dept Cell Biol & Immunol, NL-1081 BT Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands NL-1081 BT terdam, Netherlands Gambro Lundia AB, Lund, Sweden Gambro Lundia AB Lund SwedenGambro Lundia AB, Lund, Sweden
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
fascicolo: 3, volume: 16, anno: 2001,
pagine: 679 - 682
SICI:
0931-0509(200103)16:3<679:EOPFIO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIALYSIS FLUID; END-PRODUCTS; GLUCOSE; PHAGOCYTES;
Keywords:
mesothelial cells; peritoneal dialysis fluid; peritoneal immune defence; rat model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Hekking, LHP Free Univ Amsterdam, Fac Med, Dept Cell Biol & Immunol, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands Free Univ Amsterdam Van der Boechorststr 7 Amsterdam Netherlands NL-1081 BT
Citazione:
L.H.P. Hekking et al., "Effect of PD fluid instillation on the peritonitis-induced influx and bacterial clearing capacity of peritoneal cells", NEPH DIAL T, 16(3), 2001, pp. 679-682

Abstract

Background. The commonly used peritoneal dialysis fluids contain glucose as the osmotic agent. Heat sterilization leads to the formation of glucose degradation products which contribute, together with glucose, to the formation of advanced glycation end-products (AGEs). AGEs have been shown to be present in the peritoneal cavity. Methods have been developed to minimize theamount of glucose degradation products in peritoneal dialysis fluids. In arat peritoneal dialysis model, we compare the effect of a commonly used peritoneal dialysis fluid, Gambrosol(R), with a newly developed peritoneal dialysis fluid, PD-Bio(R), on the influx and functional capacity of the peritoneal cells after 2 weeks of peritoneal dialysis fluid instillation. Methods. Three groups of animals were used: rats received daily infusion with 15 ml of either 4% Gambrosol(R) (group 1) or 4% PD-Bio(R) (group 2), and a control group of animals did not receive fluid (group 3). After 2 weeksof PD fluid instillation, all the animals were injected. with a 0.5 ml suspension containing 3 x 10(8) colony-forming units of Staphylococcus aureus. The in vivo bacterial clearing capacity was determined after 15 h. Results. A statistically significant higher leukocyte influx was found in the control group compared with both PD fluid-injected groups. No statistical differences in bacterial clearing were observed among the three groups, although the number of bacteria recovered from the PD-Bio(R) group tended to be lower than that from the Gambrosol(R) group. Moreover, in both PD fluid instillation groups, the bacteria tended to be cleared more slowly compared with the control group. The number of mesothelial cells in the PD fluid groups was significantly greater than in the control group. Conclusion. No differences were observed in bacterial clearing capacity, leukocyte influx and mesothelial cell number after a 2 week exposure of the peritoneal cavity to Gambrosol(R) vs PD-Bio(R).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 04:08:24