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Titolo:
Dehydroascorbic acid and oxidative stress in haemodialysis patients
Autore:
Nakayama, H; Akiyama, S; Inagaki, M; Gotoh, Y; Oguchi, K;
Indirizzi:
Saiyu Soka Hosp, Dept Renal Med, Soka, Saitama 3400076, Japan Saiyu Soka Hosp Soka Saitama Japan 3400076 , Soka, Saitama 3400076, Japan Showa Univ, Sch Med, Dept Pharmacol, Tokyo 1428555, Japan Showa Univ Tokyo Japan 1428555 Med, Dept Pharmacol, Tokyo 1428555, Japan
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
fascicolo: 3, volume: 16, anno: 2001,
pagine: 574 - 579
SICI:
0931-0509(200103)16:3<574:DAAOSI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; WATER-SOLUBLE VITAMINS; CHRONIC-RENAL-FAILURE; ASCORBIC-ACID; HEMODIALYSIS-PATIENTS; WITHDRAWAL; PLASMA; BLOOD; SERUM;
Keywords:
ascorbic acid; dehydroascorbic acid; haemodialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Nakayama, H Tsukuba Med Ctr Hosp, Ibaraki Canc Ctr Hosp, 1-3-1 Amakubo, Tsukuba, Ibaraki 3050005, Japan Tsukuba Med Ctr Hosp 1-3-1 Amakubo Tsukuba Ibaraki Japan 3050005
Citazione:
H. Nakayama et al., "Dehydroascorbic acid and oxidative stress in haemodialysis patients", NEPH DIAL T, 16(3), 2001, pp. 574-579

Abstract

Background. The amount of dehydroascorbic acid contained within total ascorbic acid (oxidized as well as non-oxidized forms) in plasma, hereafter referred to as the dehydroascorbic acid fraction, may be a measure of oxidative stress during haemodialysis. In the present study, we determined this fraction in chronic haemodialysis patients. Methods. Using high performance liquid chromatography, dehydroascorbic acid and total ascorbic acid levels were measured in 80 maintenance haemodialysis patients for a period of >2 years as well as in 49 controls, to examinea possible association of these compounds with clinical parameters and/or drugs taken by the patients. Results. Dialysis patients who had an increased plasma urate level (P < 0.05) and had been taking allopurinol (P<0.05) or NSAID (non-steroid anti-inflammatory drugs) (P<0.01), and dialysis patients who were younger (<less than or equal to>55 years), as compared with older dialysis patients (P<0.01), were found to have a lower dehydroascorbic acid fraction by multivariate analysis. Mean plasma dehydroascorbic acid levels and dehydroascorbic acid fractions were significantly lower in the younger haemodialysis patients (4.8+/-0.7 <mu>mol/l and 28.4+/-3.9%) than in healthy younger controls (13.3+/-1.11 mu mol/l and 41.1 +/- 1.8%) (P<0.0001 and P<0.01, respectively). Moreover, a correlation was found between plasma dehydroascorbic acid fractionand plasma lipid peroxide (r=0.66, P<0.01) in patients who had not been taking allopurinol and/or NSAID. Conclusion. We found that dehydroascorbic acid fraction was related to patients' age, plasma urate level and to taking allopurinol or NSAID. Dehydroascorbic acid fraction may be another indirect index of oxidative stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 08:46:10