Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Subcutaneous formalin enhances outflow of met-enkephalin- and cholecystokinin-like materials in the rat nucleus accumbens
Autore:
Lapeyre, S; Mauborgne, A; Becker, C; Benoliel, JJ; Cesselin, F; Hamon, M; Bourgoin, S;
Indirizzi:
Fac Med Pitie Salpetriere, INSERM, U288, F-75634 Paris 13, France Fac Med Pitie Salpetriere Paris France 13 U288, F-75634 Paris 13, France
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 4, volume: 363, anno: 2001,
pagine: 399 - 406
SICI:
0028-1298(200104)363:4<399:SFEOOM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RAT; CCK-B RECEPTORS; SPINAL-CORD; ENDOGENOUS CHOLECYSTOKININ; MEDIATED ANTINOCICEPTION; MORPHINE ANALGESIA; OPIOID ANTAGONISTS; OCTAPEPTIDE CCK-8; SERINE PEPTIDASE; FRONTAL-CORTEX;
Keywords:
met-enkephalin; cholecystokinin; nucleus accumbens; formalin; naloxone; microdialysis; freely moving rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Bourgoin, S Fac Med Pitie Salpetriere, INSERM, U288, 91 Blvd Hop, F-75634 Paris 13, France Fac Med Pitie Salpetriere 91 Blvd Hop Paris France 13 France
Citazione:
S. Lapeyre et al., "Subcutaneous formalin enhances outflow of met-enkephalin- and cholecystokinin-like materials in the rat nucleus accumbens", N-S ARCH PH, 363(4), 2001, pp. 399-406

Abstract

Using the microdialysis technique, the present study investigated the effects of a noxious stimulation on the extracellular levels of met-enkephalin and (sulfated octapeptide) cholecystokinin-like materials in the nucleus accumbens of freely moving rats. Injection of 50 mul of 5% formalin into the forepaw produced pain-related behaviours associated with an immediate and sustained (for similar to2 h) increase (+27%) in the outflow of met-enkephalin-like material within the nucleus accumbens. This treatment also progressively enhanced the local outflow of cholecystokinin-like material that reached 200%-250% of the basal level at the end of the experiment, i.e. 4.5 h after formalin administration. Because naloxone (1.5 mg/kg i.p., 10 min prior to formalin injection) prevented the latter effect, it can be inferred that noxious stimulation-induced activation of cholecystokininergic neurotransmission in the nucleus accumbens probably resulted from the preceding activation of opioidergic systems. These data suggest that the nucleus accumbens may be another structure where interactions between opioids and cholecystokinin play a key role in the control of pain-processing mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:29:25