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Titolo:
Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease
Autore:
Mossner, R; Henneberg, A; Schmitt, A; Syagailo, YV; Grassle, M; Hennig, T; Simantov, R; Gerlach, M; Riederer, P; Lesch, KP;
Indirizzi:
Univ Wurzburg, Dept Psychiat, D-8700 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-8700 Psychiat, D-8700 Wurzburg, Germany Hosp Parkinsons Dis, Bad Nauheim, Germany Hosp Parkinsons Dis Bad Nauheim Germany nsons Dis, Bad Nauheim, Germany Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 enet, IL-76100 Rehovot, Israel
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 3, volume: 6, anno: 2001,
pagine: 350 - 352
SICI:
1359-4184(200105)6:3<350:AVOSTE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDASE-A GENE; FUNCTIONAL POLYMORPHISM; BINDING-SITES; PROMOTER; GENOTYPE; PAROXETINE; DISORDER; EFFICACY; ANXIETY; REGION;
Keywords:
depression; serotonin transporter; promoter; polymorphism; monoamine oxidase A; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Mossner, R Univ Wurzburg, Dept Psychiat & Psychotherapy, Fuchsleinstr 15, D-97080 Wurzburg, Germany Univ Wurzburg Fuchsleinstr 15 Wurzburg Germany D-97080 Germany
Citazione:
R. Mossner et al., "Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease", MOL PSYCHI, 6(3), 2001, pp. 350-352

Abstract

Idiopathic Parkinson's disease (PD) is a common neurodegenerative disorderwith prominent motor symptoms. However, depression is common in PD, affecting about 40% of PD patients. Since there is extensive evidence of degeneration of serotonin (5HT) neurons and loss of the 5HT transporter (5HTT) in PD, we assessed whether a functional polymorphism in the promoter of the 5HTT gene (5HTT gene-linked polymorphic region, 5HTTLPR), which determines high or low 5HT uptake, is associated with depressive symptomatology in PD patients. We found that patients with the short allele of the 5HTTLPR had significantly higher scores on the Hamilton Depression Scale. A functional promoter polymorphism of the monoamine oxidase A (MAOA) gene showed no association. Thus, the 5HTTLPR but not the MAOA gene promoter-associated polymorphism may be a risk factor for depression in PD patients, while neither polymorphism increases the risk for development of Parkinson's disease itself.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:25:44