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Titolo:
Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C
Autore:
Barr, CL; Wigg, K; Zai, G; Roberts, W; Malone, M; Schachar, R; Tannock, R; Kennedy, JL;
Indirizzi:
Toronto Western Hosp, Dept Psychiat, Toronto, ON M5T 2S8, Canada Toronto Western Hosp Toronto ON Canada M5T 2S8 oronto, ON M5T 2S8, Canada Hosp Sick Children, Dept Psychiat, Toronto, ON M5G 1X8, Canada Hosp Sick Children Toronto ON Canada M5G 1X8 Toronto, ON M5G 1X8, Canada Hosp Sick Children, Dept Paediat, Div Neurol, Toronto, ON M5G 1X8, Canada Hosp Sick Children Toronto ON Canada M5G 1X8 Toronto, ON M5G 1X8, Canada Univ Toronto, Clarke Div, Ctr Addict & Mental Hlth, Toronto, ON, Canada Univ Toronto Toronto ON Canada Addict & Mental Hlth, Toronto, ON, Canada
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 3, volume: 6, anno: 2001,
pagine: 334 - 337
SICI:
1359-4184(200105)6:3<334:AHDATA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE; LINKAGE; POLYMORPHISMS; DISABILITIES; MECHANISMS; EXPRESSION; CLONING; ADRA2C; ADHD; CDNA;
Keywords:
attention-deficit hyperactivity disorder; adrenergic receptor alpha 1C; adrenergic receptor alpha 2C; linkage; norepinephrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Barr, CL Toronto Western Hosp, Dept Psychiat, 399 Bathurst St,Room MP14-302, Toronto, ON M5T 2S8, Canada Toronto Western Hosp 399 Bathurst St,Room MP14-302 Toronto ON Canada M5T 2S8
Citazione:
C.L. Barr et al., "Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C", MOL PSYCHI, 6(3), 2001, pp. 334-337

Abstract

The adrenergic system has been hypothesized to be involved in the etiologyof attention-deficit hyperactivity disorder (ADHD) based on pharmacological interventions and animal models. Noradrenergic neurons are implicated in the modulation of vigilance, improvement of visual attention, initiation ofadaptive response, learning and memory. In this study we tested the genes for two adrenergic receptors, alpha 1C (ADRA1C) located on chromosome 8p11.2, and alpha 2C (ADRA2C) located on chromosome 4p16, as genetic susceptibility factors in ADHD. For the adrenergic receptor alpha 1C we used a C to T polymorphism that results in a change of Cys to Arg at codon 492 for the linkage study. For the adrenergic receptor alpha 2C gene we examined a dinucleotide repeat polymorphism located approximately 6 kb from the gene. We examined these polymorphisms in a sample of 103 families ascertained through an ADHD proband. Using the transmission disequilibrium test, we did not observe biased transmission of any of the alleles of these polymorphisms. We conclude that the alleles at the polymorphisms tested in these two genes are not linked to the ADHD phenotype in this sample of families.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:41:28