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Titolo:
Low avidity of human serum antibodies for Borna disease virus antigens questions their diagnostic value
Autore:
Allmang, U; Hofer, M; Herzog, S; Bechter, K; Staeheli, P;
Indirizzi:
Univ Freiburg, Inst Med Mikrobiol & Hyg, Abt Virol, D-79104 Freiburg, Germany Univ Freiburg Freiburg Germany D-79104 Virol, D-79104 Freiburg, Germany Univ Giessen, Inst Virol, D-35392 Giessen, Germany Univ Giessen Giessen Germany D-35392 nst Virol, D-35392 Giessen, Germany Univ Ulm, Abt Psychiat 2, Bezirkskrankenhaus Gunzburg, D-89312 Gunzburg, Germany Univ Ulm Gunzburg Germany D-89312 us Gunzburg, D-89312 Gunzburg, Germany
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 3, volume: 6, anno: 2001,
pagine: 329 - 333
SICI:
1359-4184(200105)6:3<329:LAOHSA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
REACTIVE ANTIBODIES; PSYCHIATRIC-DISORDERS; BLOOD-DONORS; INFECTION; PREVALENCE; RNA;
Keywords:
Borna disease virus; serum antibodies; avidity; indirect immunofluorescence analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Staeheli, P Univ Freiburg, Dept Virol, Hermann Herder Str 11, D-79008 Freiburg, Germany Univ Freiburg Hermann Herder Str 11 Freiburg Germany D-79008
Citazione:
U. Allmang et al., "Low avidity of human serum antibodies for Borna disease virus antigens questions their diagnostic value", MOL PSYCHI, 6(3), 2001, pp. 329-333

Abstract

Borna disease virus (BDV) can induce neurological disease in animals.(1,2)Since viral nucleic acid,(3-5) infectious particles(6-8) and antibodies recognizing BDV antigens(9-11) were found at higher frequencies in psychiatric patients than in healthy controls, BDV is suspected to cause psychiatric disorders in humans. However, the human origin of these viruses has recently been questioned.(12) To diagnose BDV infections, sera are usually analyzed for antiviral antibodies by indirect immunofluorescence (IFA) on virus-infected cells.(9,10,13) This study reveals that the reactive antibodies in human sera mainly recognized the BDV phosphoprotein, whereas animal sera preferentially detected the viral nucleoprotein. Immunoglobulin (Ig)G in sera of experimentally or naturally infected animals bound to the viral antigen with high avidity, ie resisting 3 M urea, whereas reactive IgG in human sera did not. Longitudinal studies showed that reactive human antibodies persisted for many years without gaining high avidity for BDV antigens, indicating that they were probably not induced by BDV but rather by infection with an antigenically related microorganism of unknown identity or by exposure to other related immunogens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:08:23