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Titolo:
Exon 3 of tyrosine hydroxylase gene: lack of association with Japanese schizophrenic patients
Autore:
Ota, M; Nakashima, A; Ikemoto, K; Nojima, S; Tanaka, M; Okuda, M; Koga, H; Mori, K; Kaneko, YS; Fujiwara, K; Yamamoto, H; Nagatsu, T; Ota, A;
Indirizzi:
Fujita Hlth Univ, Sch Med, Dept Physiol, Aichi 4701192, Japan Fujita Hlth Univ Aichi Japan 4701192 Dept Physiol, Aichi 4701192, Japan Tosei Gen Hosp, Dept Neuropsychiat, Seto 4868642, Japan Tosei Gen Hosp Seto Japan 4868642 ept Neuropsychiat, Seto 4868642, Japan Nagoya City Univ, Sch Med, Dept Psychiat, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Fujita Hlth Univ, Sch Med, Dept Anat, Aichi 4701192, Japan Fujita Hlth Univ Aichi Japan 4701192 ed, Dept Anat, Aichi 4701192, Japan Fujita Hlth Univ, Sch Med, Dept Neurol, Aichi 4701192, Japan Fujita Hlth Univ Aichi Japan 4701192 , Dept Neurol, Aichi 4701192, Japan Fujita Hlth Univ, Sch Med, Dept Internal Med, Aichi 4701192, Japan Fujita Hlth Univ Aichi Japan 4701192 Internal Med, Aichi 4701192, Japan Kitatsushima Hosp, Heiwa 4901300, Japan Kitatsushima Hosp Heiwa Japan 4901300 sushima Hosp, Heiwa 4901300, Japan Minamichita Hosp, Minamichita 4703411, Japan Minamichita Hosp Minamichita Japan 4703411 p, Minamichita 4703411, Japan Yagoto Hosp, Nagoya, Aichi 4680073, Japan Yagoto Hosp Nagoya Aichi Japan 4680073 Hosp, Nagoya, Aichi 4680073, Japan Fujita Hlth Univ, Inst Comprehens Med Sci, Toyoake, Aichi 4701192, Japan Fujita Hlth Univ Toyoake Aichi Japan 4701192 oyoake, Aichi 4701192, Japan
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 3, volume: 6, anno: 2001,
pagine: 315 - 319
SICI:
1359-4184(200105)6:3<315:E3OTHG>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POINT MUTATION; DOPAMINE-INHIBITION; FIRST INTRON; N-TERMINUS; TYPE-1; POLYMORPHISM; DISTURBANCES; STRIATUM; DISEASE; TH;
Keywords:
schizophrenia; tyrosine hydroxylase gene; exon 3; dopamine inhibition; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Ota, A Fujita Hlth Univ, Sch Med, Dept Physiol, Aichi 4701192, Japan Fujita Hlth Univ Aichi Japan 4701192 hysiol, Aichi 4701192, Japan
Citazione:
M. Ota et al., "Exon 3 of tyrosine hydroxylase gene: lack of association with Japanese schizophrenic patients", MOL PSYCHI, 6(3), 2001, pp. 315-319

Abstract

Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine (DA) biosynthesis.(1,2) Exon 3 of the human TH gene encodes the sequence from Ser31to Glu104 of type 1 enzyme,(3,4) which contains the critical parts for regulation of the catalytic activity. The amino acid residues Gly36-Arg37-Arg38 were identified as a key sequence for DA to exert its inhibitory effect on catalytic activity.(5-7) Therefore, we screened the nucleotide sequences of exon 3 from 201 Japanese patients with schizophrenia to explain the elevation in the synaptic or presynaptic DA concentrations in the schizophrenicbrain,(8-11) based on the hypothesis that any mutation changing the amino acid sequence Gly36-Arg37-Arg38 would result in the elevation of DA synthesis, due to a reduced inhibitory effect of DA on the catalytic activity.(5-7) However, no mutated sequences of exon 3 and both exon-intron boundaries were detected in any of the patients examined. Polymorphisms generating Val81 and Met81 were compared of the distributions of genotype and allele between the patients and 175 Japanese healthy controls, which did not suggest anassociation between the polymorphism and schizophrenia. These results indicate that exon 3 of the human TH gene lacks association with schizophrenia in Japanese patients.

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Documento generato il 28/01/20 alle ore 15:15:25