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Titolo:
Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia
Autore:
Mirnics, K; Middleton, FA; Stanwood, GD; Lewis, DA; Levitt, P;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 sychiat, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 urobiol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, Dept Neurosci, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 eurosci, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, PittArray, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 ttArray, Pittsburgh, PA 15261 USA
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 3, volume: 6, anno: 2001,
pagine: 293 - 301
SICI:
1359-4184(200105)6:3<293:DCIROG>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; DRUG-NAIVE SCHIZOPHRENICS; PREFRONTAL CORTEX; ANTIPSYCHOTIC-DRUGS; DOPAMINE-RECEPTOR; RAT-BRAIN; GENE-EXPRESSION; ALPHA-SUBUNITS; D-2 RECEPTORS; NEUROPATHOLOGY;
Keywords:
schizophrenia; major depression; antipsychotic; haloperidol; gene expression; regulator of G-protein signaling; RGS4; microarray; prefrontal; cerebral cortex; susceptibility gene; 1q21-22;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Mirnics, K Univ Pittsburgh, Sch Med, Dept Psychiat, E1602 BST, Pittsburgh,PA 15261 USA Univ Pittsburgh E1602 BST Pittsburgh PA USA 15261 PA 15261 USA
Citazione:
K. Mirnics et al., "Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia", MOL PSYCHI, 6(3), 2001, pp. 293-301

Abstract

Complex defects in neuronal signaling may underlie the dysfunctions that characterize schizophrenia. Using cDNA microarrays, we discovered that the transcript encoding regulator of G-protein signaling 4 (RGS4) was the most consistently and significantly decreased in the prefrontal cortex of all schizophrenic subjects examined. The expression levels of ten other RGS familymembers represented on the microarrays were unchanged and hierarchical data analysis revealed that as a group, 274 genes associated with G-protein signaling were unchanged. Quantitative in situ hybridization verified the microarray RGS4 data, and demonstrated highly correlated decreases in RGS4 expression across three cortical areas of ten subjects with schizophrenia, RGS4 expression was not altered in the prefrontal cortex of subjects with major depressive disorder or in monkeys treated chronically with haloperidol. Interestingly, targets for 70 genes mapped to the major schizophrenia susceptibility locus 1q21-22 were present on the microarrays, of which only RGS4 gene expression was consistently altered. The combined data indicate that adecrease in RGS4 expression may be a common and specific feature of schizophrenia, which could be due either to genetic factors or a disease-specificadaptation, both of which could affect neuronal signaling.

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Documento generato il 23/10/20 alle ore 13:54:02