Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Suicide attempts and the tryptophan hydroxylase gene
Autore:
Abbar, M; Courtet, P; Bellivier, F; Leboyer, H; Boulenger, JP; Castelhau, D; Ferreira, M; Lambercy, C; Mouthon, D; Paoloni-Giacobino, A; Vessaz, M; Malafosse, A; Buresi, C;
Indirizzi:
Lapeyronie Hosp, Dept Psychol Med & Psychiat, INSERM, F-34295 Montpellier 5, France Lapeyronie Hosp Montpellier France 5 SERM, F-34295 Montpellier 5, France Caremeau Hosp, Dept Psychiat, Nimes, France Caremeau Hosp Nimes FranceCaremeau Hosp, Dept Psychiat, Nimes, France Henri Mondor & Albert Chenevier Hosp, Dept Psychiat, Creteil, France HenriMondor & Albert Chenevier Hosp Creteil France at, Creteil, France La Colombiere Hosp, Univ Dept Psychiat, INSERM, Montpellier, France La Colombiere Hosp Montpellier France hiat, INSERM, Montpellier, France Univ Hosp Geneva, Dept Psychiat, Div Neuropsychiat, Geneva, Switzerland Univ Hosp Geneva Geneva Switzerland Neuropsychiat, Geneva, Switzerland
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 3, volume: 6, anno: 2001,
pagine: 268 - 273
SICI:
1359-4184(200105)6:3<268:SAATTH>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; BEHAVIOR; ASSOCIATION; POLYMORPHISM; IDENTIFICATION; SEQUENCE; VARIANTS;
Keywords:
tryptophan hydroxylase; genetic polymorphisms; suicidal behavior; association study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Courtet, P Lapeyronie Hosp, Dept Psychol Med & Psychiat, INSERM, E99-30, F-34295 Montpellier 5, France Lapeyronie Hosp E99-30 Montpellier France 5 tpellier 5, France
Citazione:
M. Abbar et al., "Suicide attempts and the tryptophan hydroxylase gene", MOL PSYCHI, 6(3), 2001, pp. 268-273

Abstract

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme of serotonin synthesis. In this case-control study, we investigated whether the TPH gene wasa susceptibility factor for suicidal behavior. Seven polymorphisms spanning the entire gene were studied in a case-control study including 231 individuals who had attempted suicide and 281 controls. Significant associations were found between variants in introns 7, 8 and 9 (chi (2) = 11.2, df = 1, P<0.0008 for the allele distribution; these loci are in complete linkage disequilibrium) and in the 3' noncoding region (<chi>(2) = 30.94, P= 0.0014) and suicide attempt. The association was strongest for subjects who had attempted suicide by violent means and who had a history of major depression. No significant association was observed between suicide attempts and polymorphisms in the promoter, intron 1 and intron 3. The results presented here,and those of previous studies, suggest that a genetic variant of the 3' part of the TPH gene may be a susceptibility factor for a phenotype combiningsuicidal behavior, mood disorder and impulsive aggression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 01:59:31