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Titolo:
EFFECT OF NEUROLEPTIC TREATMENT ON DEPRESSIVE SYMPTOMS IN ACUTE SCHIZOPHRENIC EPISODES
Autore:
KRAKOWSKI M; CZOBOR P; VOLAVKA J;
Indirizzi:
NATHAN S KLINE INST PSYCHIAT RES,140 OLD ORANGEBURG RD NEW YORK NY 10962
Titolo Testata:
Psychiatry research
fascicolo: 1, volume: 71, anno: 1997,
pagine: 19 - 26
SICI:
0165-1781(1997)71:1<19:EONTOD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE SYMPTOMS; AKINESIA; SCALE; MOOD;
Keywords:
NEUROLEPTIC EFFECTS; PLASMA LEVELS; EXTRAPYRAMIDAL SYMPTOMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
M. Krakowski et al., "EFFECT OF NEUROLEPTIC TREATMENT ON DEPRESSIVE SYMPTOMS IN ACUTE SCHIZOPHRENIC EPISODES", Psychiatry research, 71(1), 1997, pp. 19-26

Abstract

This study examined depressive symptoms in acute schizophrenic episodes and their relationship to neuroleptic treatment. Sixty-three depressed and 62 non-depressed acutely exacerbated schizophrenic patients were evaluated with the Brief Psychiatric Rating Scare, the Scale for the Assessment of Positive Symptoms, the Simpson-Angus Extrapyramidal Scale, and the Hamilton Rating Scale for Depression. Subjects were then randomly assigned to different haloperidol plasma levels and followed for 3 weeks. Overall, depression improved with treatment of the acute psychosis, but a positive association between extrapyramidal side effects and depressive symptoms emerged over time. Depressive symptoms tended to be positively related to haloperidol plasma levels. The resultssuggest that depressive symptoms in schizophrenia are heterogeneous in origin; while neuroleptics can ameliorate depressive symptoms inherent in the acute schizophrenic episode, they can also contribute to depression. (C) 1997 Elsevier Science Ireland Ltd.

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Documento generato il 25/01/20 alle ore 03:23:45