Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dopamine D-1 receptor expression in human basal ganglia and changes in Parkinson's disease
Autore:
Hurley, MJ; Mash, DC; Jenner, P;
Indirizzi:
Univ Miami, Sch Med, Dept Neurol, Miami, FL 33136 USA Univ Miami Miami FLUSA 33136 , Sch Med, Dept Neurol, Miami, FL 33136 USA Univ London Kings Coll, Guys Kings & St Thomas Sch Biomed Sci, Neurodegenerat Dis Res Ctr, London SE1 1UL, England Univ London Kings Coll London England SE1 1UL r, London SE1 1UL, England
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 2, volume: 87, anno: 2001,
pagine: 271 - 279
SICI:
0169-328X(20010305)87:2<271:DDREIH>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEVODOPA-INDUCED DYSKINESIA; MPTP-INDUCED PARKINSONISM; MESSENGER-RNA; RAT-BRAIN; SUBTHALAMIC NUCLEUS; SUPRANUCLEAR PALSY; STRIATAL NEURONS; H-3 SCH-23390; D1 AGONIST; CY 208-243;
Keywords:
basal ganglia; dopamine D-1 receptor; Parkinson's disease; radioligand binding; RT-PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Hurley, MJ Inst Child Hlth, Div Cell & Mol Biol, Neural Dev Unit, 30 Guilford St, London WC1N 1EH, England Inst Child Hlth 30 Guilford St London England WC1N 1EH England
Citazione:
M.J. Hurley et al., "Dopamine D-1 receptor expression in human basal ganglia and changes in Parkinson's disease", MOL BRAIN R, 87(2), 2001, pp. 271-279

Abstract

The expression of the human dopamine D-1 receptor was examined by reverse transcription polymerase chain reaction (RT-PCR) and radioligand binding using [H-3]-SCH23390 in post-mortem brain tissue that was obtained from normal subjects and patients dying with Parkinson's disease who were receiving treatment with dopaminergic drugs. D-1 receptor mRNA and specific [H-3]-SCH23390 binding sites were found in both striatal (nucleus accumbens, caudate nucleus and putamen) and extrastriatal (globus pallidus and substantia nigra) brain regions. In parkinsonian brain, D-1 receptor mRNA was increased inthe nucleus accumbens, while a decrease was detected in the substantia nigra pars compacta. No change in D-1 mRNA levels was found in the other brainareas examined. An increase in the density of specific [H-3]-SCH23390 binding sites was found in the anterior putamen and a decrease in the external segment of the globus pallidus, no changes were detected elsewhere. This study demonstrates that regulation of D-1 receptor expression in the brain ofpatients dying with Parkinson's disease that were treated with L-DOPA is confined to small alterations in restricted brain regions. (C) 2001 ElsevierScience B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:01:16