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Titolo:
Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation
Autore:
Dull, RO; Yuan, J; Chang, YS; Tarbell, J; Jain, RK; Munn, LL;
Indirizzi:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Radiat Oncol,Edwin L Steele Lab, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 Edwin L Steele Lab, Boston, MA 02114 USA Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 n, University Pk, PA 16802 USA
Titolo Testata:
MICROVASCULAR RESEARCH
fascicolo: 2, volume: 61, anno: 2001,
pagine: 203 - 210
SICI:
0026-2862(200103)61:2<203:KOPGFE>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR-PERMEABILITY FACTOR; CELL GROWTH; FLT-1; BINDING; FLK-1/KDR; RECEPTORS; KINASE; KDR; IDENTIFICATION; ANGIOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Dull, RO Johns Hopkins Univ, Sch Med, Dept Anesthesia & Crit Care Med, Baltimore, MD 21218 USA Johns Hopkins Univ Baltimore MD USA 21218 altimore, MD 21218 USA
Citazione:
R.O. Dull et al., "Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation", MICROVASC R, 61(2), 2001, pp. 203-210

Abstract

Vascular endothelial growth factor (VEGF) was originally discovered as vascular permeability factor because of its ability to increase microvascular permeability to plasma proteins. Since then, it has been shown to induce proliferation and migration in endothelial cells. Placenta growth factor (PlGF) is a member of the VEGF family of growth factors, but has little or undetectable mitogenic activity on endothelial cells. Intriguingly, however, PlGF was able to potentiate the action of low concentrations of VEGF on endothelial cell growth and macromolecule permeability in vitro. Here we show that PlGF can potentiate the effects of VEGF on the hydraulic conductivity ofcertain endothelial cells and that the duration of pretreatment with PlGF determines the resulting response. Hydraulic conductivity (Lp) was calculated from the water flux across the monolayer of human umbilical vein endothelial cells (HUVECs) or bovine aortic endothelial cells (BAECs). After 2 h of exposure to VEGF(165), the Lp of BAEC monolayers increased threefold, butthe Lp of HUVEC monolayers did not increase. PlGF alone induced a small (63%) increase in Lp in BAECs, but not in HUVECs. BAEC, but not HUVEC, monolayers exposed first to PlGF and then to VEGF exhibited a seven- to eightfoldincrease in Lp. This enhancement in BAEC Lp could be observed for 4 h after the administration of PlGF. PlGF also potentiated the effect of VEGF on BAEC proliferation. Thus, augmentation of VEGF action by PlGF depends on theduration of PlGF exposure and on the origin of endothelial cells. (C) 2001Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:06:59