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Titolo:
Membrane traffic in myelinating oligodendrocytes
Autore:
Kramer, EM; Schardt, A; Nave, KA;
Indirizzi:
Max Planck Inst Expt Med, Dept Neurogenet, D-37035 Gottingen, Germany Max Planck Inst Expt Med Gottingen Germany D-37035 35 Gottingen, Germany
Titolo Testata:
MICROSCOPY RESEARCH AND TECHNIQUE
fascicolo: 6, volume: 52, anno: 2001,
pagine: 656 - 671
SICI:
1059-910X(20010315)52:6<656:MTIMO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLARIZED EPITHELIAL-CELLS; GTP-BINDING PROTEINS; CANINE KIDNEY-CELLS; 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE; PELIZAEUS-MERZBACHER-DISEASE; APICAL PLASMA-MEMBRANE; CENTRAL-NERVOUS-SYSTEM; CARBONIC-ANHYDRASE-II; CULTURED GLIAL-CELLS; PROTEOLIPID PROTEIN;
Keywords:
membrane domains; myelin assembly; protein sorting; vesicle trafficking; mistrafficking; disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
148
Recensione:
Indirizzi per estratti:
Indirizzo: Kramer, EM Max Planck Inst Expt Med, Dept Neurogenet, Hermann Rein Str 3, D-37035 Gottingen, Germany Max Planck Inst Expt Med Hermann Rein Str 3 Gottingen Germany D-37035
Citazione:
E.M. Kramer et al., "Membrane traffic in myelinating oligodendrocytes", MICROSC RES, 52(6), 2001, pp. 656-671

Abstract

In the central nervous system (CNS), the myelin sheath is synthesised by oligodendrocytes as a specialised subdomain of an extended plasma membrane, reminiscent of the segregated membrane domains of polarised cells. Myelination takes place within a relatively short period of time and oligodendrocytes must have adapted membrane sorting and transport mechanisms to achieve such a high rate of myelin synthesis and to maintain the unique organisationof the myelin membrane. In adult life, maintenance of the functional myelin sheath requires a carefully orchestrated balance of myelin synthesis and turnover. Imbalance in these processes may cause dys- or demyelination and disease. This review summarises what is currently known about myelin protein trafficking and mistrafficking in oligodendrocytes. We also present data demonstrating distinct transport pathways for myelin structural proteins and the expression of SNARE proteins in differentiating oligodendrocytes. Myelinating glial cells may well serve as a model system for studying general aspects of membrane trafficking and organisation of membrane domains. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:33:50