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Titolo:
Isolation, sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population
Autore:
Isaza, CA; Henao, J; Lopez, AM; Cacabelos, R;
Indirizzi:
EuroEspes Biomed Res Ctr, Inst CNS Disorders, Dept Clin Neurosci, La Coruna 15166, Spain EuroEspes Biomed Res Ctr La Coruna Spain 15166 i, La Coruna 15166, Spain Pereira Technol Univ, Sch Med, Med Genet Lab, Pereira, Colombia Pereira Technol Univ Pereira Colombia Med Genet Lab, Pereira, Colombia
Titolo Testata:
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
fascicolo: 9, volume: 22, anno: 2000,
pagine: 695 - 705
SICI:
0379-0355(200011)22:9<695:ISAGOT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEXTROMETHORPHAN O-DEMETHYLATION; POOR METABOLIZERS; DEBRISOQUINE 4-HYDROXYLASE; ULTRARAPID METABOLISM; CHINESE POPULATION; PARKINSONS-DISEASE; HUMAN-LIVER; POLYMORPHISM; ALLELES; PHENOTYPE;
Keywords:
cytochrome P450; CYP2D6 gene; drug metabolism; genetic polymorphism; pharmacogenetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Cacabelos, R EuroEspes Biomed Res Ctr, Inst CNS Disorders, Dept Clin Neurosci, La Coruna 15166, Spain EuroEspes Biomed Res Ctr La Coruna Spain 15166 15166, Spain
Citazione:
C.A. Isaza et al., "Isolation, sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population", METH FIND E, 22(9), 2000, pp. 695-705

Abstract

Cytochrome P450 2D6 monooxygenase metabolizes several commonly used drugs,particularly psychotropics and cardiovascular agents. The gene that encodes this isoenzyme is highly polymorphic, with 1-10% of the population carrying mutations that produce an inactive enzyme, and 1-29% of individuals who possess additional copies of functional CYP2D6 genes. The genotypic features of the CYP2D6 gene have already been studied in many ethnic groups; however, the genetic characteristics of this enzyme are unknown in the Columbianpopulation. The allelic variants and mutations of this polymorphic isoenzyme are the main cause of interindividual and interethnic differences in thetherapeutic efficacy and adverse effects at standard doses of drugs metabolized by the products of the CYP2D6 gene. In the present study we have isolated, sequenced and genotyped the CYP2D6 gene in the Colombian population. The distribution of allelic frequencies of 10 alleles associated with normal, diminished or increased CYP2D6 activity has been studied in 121 healthy volunteers. The commonest alleles detected in the Colombian people were thefunctional alleles *1 (38.8%) and *2 (37%). Among the seven nonfunctional alleles studied in our sample, we found frequencies of 19.4%, 1.6%, 1.2% and 0.8%, for the *4, *17, *3 and *5 alleles, respectively. The alleles *6, *7 and *8 could not be identified in any of the subjects studied. The frequency of the duplicate allele was 1.2%. In this Columbian sample, 91.7% of the individuals were normal metabolizers (EM), 6.6% were poor metabolizers (PM), and 1.7% were ultrarapid metabolizers (UM). These results show that theallelic distribution of the CYP2D6 gene in the Columbian population of mestizo-prevalent subjects is compatible with the genomic assembly of the constitutive tri-ethnic origin of this Latin American country. (C) 2000 Prous Science. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:23:18