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Titolo:
Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo
Autore:
Holzschuh, J; Ryu, S; Aberger, F; Driever, W;
Indirizzi:
Univ Freiburg, Inst Biol 1, Dept Dev Biol, D-79104 Freiburg, Germany Univ Freiburg Freiburg Germany D-79104 v Biol, D-79104 Freiburg, Germany
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 101, anno: 2001,
pagine: 237 - 243
SICI:
0925-4773(200103)101:1-2<237:DTEDDN>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE-HYDROXYLASE; MESSENGER-RNA; MOLECULAR-CLONING; MIDBRAIN NEURONS; LOCUS-COERULEUS; LOCALIZATION; ORGANIZATION; SYSTEMS; PATHWAYS; PATTERN;
Keywords:
zebrafish; dopaminergic system; catecholaminergic system; tyrosine hydroxylase; dopamine transporter; diencephalon; olfactory bulb; pretectum; retina; locus coeruleus; medulla; carotid body; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Driever, W Univ Freiburg, Inst Biol 1, Dept Dev Biol, Hauptstr 1, D-79104 Freiburg, Germany Univ Freiburg Hauptstr 1 Freiburg Germany D-79104 urg, Germany
Citazione:
J. Holzschuh et al., "Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo", MECH DEVEL, 101(1-2), 2001, pp. 237-243

Abstract

To characterize the formation of the dopaminergic system in the developingzebrafish CNS, we cloned cDNAs encoding tyrosine hydroxylase (th), an enzyme in dopamine synthesis, and the dopamine transporter (dat). a membrane transport protein which terminates dopamine action by re-uptake, Dopaminergicneurons are first detected between IS and 19 h post-fertilization in a cluster of cells in the ventral diencephalon. Subsequently, th and dat detection identifies dopaminergic neurons in the olfactory bulb, the pretectum. the retina and the locus coeruleus. Neurons expressing rh but not dat are adrenergic or noradrenergic, and are found in the locus coeruleus, the medulla. the likely analog of the carotid body, and precursors of the enteric and sympathetic nervous system. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:17:26