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Titolo:
Stem cells and the regulation of proliferation, differentiation and patterning in the intestinal epithelium: emerging insights from gene expression patterns, transgenic and gene ablation studies
Autore:
Clatworthy, JP; Subramanian, V;
Indirizzi:
Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England Univ Bath Bath Avon England BA2 7AY Biochem, Bath BA2 7AY, Avon, England
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 101, anno: 2001,
pagine: 3 - 9
SICI:
0925-4773(200103)101:1-2<3:SCATRO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE SMALL-INTESTINE; EMBRYONIC INTESTINE; CYCLIN E-CDK2; MICE; PROTEIN; CDX1; RENEWAL; ORIGIN; REGENERATION; ACTIVATION;
Keywords:
intestine; epithelium; stem cells; molecular markers; culture; proliferation; transgenic; targeted deletion;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Subramanian, V Univ Bath, Dept Biol & Biochem, South Bldg, Bath BA2 7AY, Avon, England Univ Bath South Bldg Bath Avon England BA2 7AY von, England
Citazione:
J.P. Clatworthy e V. Subramanian, "Stem cells and the regulation of proliferation, differentiation and patterning in the intestinal epithelium: emerging insights from gene expression patterns, transgenic and gene ablation studies", MECH DEVEL, 101(1-2), 2001, pp. 3-9

Abstract

Tissues that undergo self-renewal such as the skin, the haematopoeitic system and the intestine are all maintained and renewed by a small group of multipotent stem cells. The stem cells of the intestinal epithelium are located in the crypts and give rise to its four main lineages located mainly in the finger like projections- the villi. Rn increasing number of genes are now being identified as either bring necessary for or involved in the maintenance of intestinal stem cells and regulating differentiation along the crypt-villus axis. These developmental regulatory genes include among others, Tcf-4, Cdx-1 Fkh6, HFH11 and Nkx2-3. Other genes such as the integrins, andIndian hedgehog (Ihh) also affect function of the progenitor cells of the intestinal epithelium. This mini-review will focus on the more recent data on expression patterns of genes in the intestinal epithelium and the director indirect effects of their ablation on proliferation and differentiation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:29:58