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Titolo:
Inverse relationship between plasma epinephrine and testosterone levels during acute glucoprivation in healthy men
Autore:
Elman, I; Goldstein, DS; Adler, CM; Shoaf, SE; Breier, A;
Indirizzi:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat,Addict Serv, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 ychiat,Addict Serv, Boston, MA 02114 USA NINDS, Clin Cardiol Sect, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 DS, Clin Cardiol Sect, Bethesda, MD 20892 USA NIMH, Expt Therapeut Branch, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 Expt Therapeut Branch, Bethesda, MD 20892 USA NIAAA, Clin Studies Lab, Bethesda, MD 20892 USA NIAAA Bethesda MD USA 20892 AAA, Clin Studies Lab, Bethesda, MD 20892 USA Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USAEli Lilly & Co Indianapolis IN USA 46285 Labs, Indianapolis, IN 46285 USA Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ychiat, Indianapolis, IN 46202 USA
Titolo Testata:
LIFE SCIENCES
fascicolo: 16, volume: 68, anno: 2001,
pagine: 1889 - 1898
SICI:
0024-3205(20010309)68:16<1889:IRBPEA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-INDUCED HYPOGLYCEMIA; HOMOVANILLIC-ACID; 5-HYDROXYINDOLEACETIC ACID; NOREPINEPHRINE UPTAKE; CEREBROSPINAL-FLUID; BLOOD-FLOW; CATECHOLAMINES; STRESS; BRAIN; RATS;
Keywords:
deoxyglucose; stress; catecholamines; norepinephrine; HVA; 5-HIAA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Elman, I Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat,Addict Serv, 15 Parkman St WACC-812, Boston, MA 02114 USA Harvard Univ 15 Parkman St WACC-812 Boston MA USA 02114 02114 USA
Citazione:
I. Elman et al., "Inverse relationship between plasma epinephrine and testosterone levels during acute glucoprivation in healthy men", LIFE SCI, 68(16), 2001, pp. 1889-1898

Abstract

In healthy men, a decrease in plasma testosterone levels was observed in the context of metabolic stress. While physiological mechanisms underlying this response are unclear, there are several lines of evidence suggesting circulating epinephrine's influence on plasma testosterone levels. The purpose of this study was to directly relate stress-induced changes in plasma testosterone and epinephrine. The stressor used was blockade of glucose metabolism with pharmacological doses (40mg/kg) of 2 deoxyglucose (2DG). Arterialplasma samples from 10 healthy males were assayed at 20 minutes intervals for 60 minutes for the concentrations of testosterone, epinephrine and related biochemicals. Bolus administration of 2DG resulted in progressive decline in testosterone and increases in epinephrine and norepinephrine plasma levels (mean change from baseline: 29, 2530 and 186%, respectively). Inversecorrelation was detected between both absolute (r(s)= -0.72; df=8; p=0.017) and baseline-corrected testosterone concentrations at the 60 minute time point and epinephrine area under the curve values. Our results suggest thatadrenomedullary activation may be involved in stress-induced testosterone effects. The implications of these data for the understanding of the role of catecholamines in glucoprivic stress response are discussed. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 27/09/20 alle ore 21:53:53