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Titolo:
Bezafibrate attenuates the overexpression of plasminogen activator inhibitor-1 messenger RNA by a combination of mono-unsaturated fatty acid and insulin in HepG2 cells
Autore:
Suzuki, Y; Urano, T; Ihara, H; Nakajima, T; Nagai, N; Takada, Y; Taminato, T; Takada, A;
Indirizzi:
Hamamatsu Univ, Sch Med, Dept Physiol, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan St Marianna Univ, Sch Med, Dept Gynecol, Kawasaki, Kanagawa, Japan St Marianna Univ Kawasaki Kanagawa Japan ecol, Kawasaki, Kanagawa, Japan Hamamatsu Univ, Sch Med, Dept Pathophysiol, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Kagawa Univ, Sch Med, Dept Lab Med, Takamatsu, Kagawa 760, Japan Kagawa Univ Takamatsu Kagawa Japan 760 Med, Takamatsu, Kagawa 760, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 16, volume: 68, anno: 2001,
pagine: 1827 - 1837
SICI:
0024-3205(20010309)68:16<1827:BATOOP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EUGLOBULIN CLOT LYSIS; GENE-EXPRESSION; FIBRINOLYTIC-ACTIVITY; CULTURED-HEPATOCYTES; CYNOMOLGUS MONKEY; ENDOTHELIAL-CELLS; RECEPTOR-ALPHA; TYPE-1; GEMFIBROZIL; HYPERTRIGLYCERIDEMIA;
Keywords:
bezafibrate; PAI-1; fatty acid; insulin; troglitazone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Takada, A Hamamatsu Univ, Sch Med, Dept Physiol, 3600 Handa, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ 3600 Handa Hamamatsu Shizuoka Japan 4313192 Japan
Citazione:
Y. Suzuki et al., "Bezafibrate attenuates the overexpression of plasminogen activator inhibitor-1 messenger RNA by a combination of mono-unsaturated fatty acid and insulin in HepG2 cells", LIFE SCI, 68(16), 2001, pp. 1827-1837

Abstract

The effects of bezafibrate (PPAR alpha activator) and troglitazone (PPAR gamma activator) on the expression of plasminogen activator inhibitor type-1(PAI-1) in HepG2 cells were investigated. Exposure of the cells for 24 hours to either oleic acid or insulin showed no obvious effects on PAI-1 synthesis, whereas the combination of the two agents induced a 2.3-fold increasein PAI-1 synthesis, which was accompanied by a 3-fold increase in both the2.2 kb and 3.2 kb forms of PAI-1 mRNA. This up-regulation of PAI-1 synthesis was attenuated by bezafibrate in a dose-dependent manner (1-100 muM) with 30 % reversal at 100 muM. In contrast, troglitazone further stimulated PAI-1 synthesis to 140 % of the level obtained in the presence of both oleic acid and insulin. This attenuation by bezafibrate and enhancement by troglitazone required the presence of both oleic acid and insulin. It is interesting that PAI-1 expression was affected so differently by these two PPAR activators. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/18 alle ore 08:52:24