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Titolo:
Using death to one's advantage: HIV modulation of apoptosis
Autore:
Ross, TM;
Indirizzi:
E Carolina Univ, Brody Sch Med, Dept Microbiol & Immunol, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 Immunol, Greenville, NC 27858 USA
Titolo Testata:
LEUKEMIA
fascicolo: 3, volume: 15, anno: 2001,
pagine: 332 - 341
SICI:
0887-6924(200103)15:3<332:UDTOAH>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; FAS LIGAND EXPRESSION; PROGRAMMED CELL-DEATH; TYPE-1 TAT PROTEIN; CD4(+) T-CELLS; INTERLEUKIN-1-BETA CONVERTING-ENZYME; FOCAL ADHESION KINASE; TUMOR-NECROSIS-FACTOR; MUTATIONAL ANALYSIS; CYCLE ARREST;
Keywords:
HIV; AIDS; T cell depletion; apoptosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
152
Recensione:
Indirizzi per estratti:
Indirizzo: Ross, TM E Carolina Univ, Brody Sch Med, Dept Microbiol & Immunol, Brody Hlth SciBldg,600 Moye Blvd, Greenville, NC 27858 USA E Carolina Univ Brody Hlth SciBldg,600 Moye Blvd Greenville NC USA 27858
Citazione:
T.M. Ross, "Using death to one's advantage: HIV modulation of apoptosis", LEUKEMIA, 15(3), 2001, pp. 332-341

Abstract

Infection by human immunodeficiency virus (HIV) is associated with an early immune dysfunction and progressive destruction of CD4(+) T lymphocytes. This progressive disappearance of T cells leads to a lack of immune control of HIV replication and to the development of immune deficiency resulting inthe increased occurrence of opportunistic infections associated with acquired immune deficiency syndrome (AIDS), The HIV-induced, premature destruction of lymphocytes is associated with the continuous production of HIV viralproteins that modulate apoptotic pathways. The viral proteins, such as Tat, Env, and Nef, are associated with chronic immune activation and the continuous induction of apoptotic factors. Viral protein expression predisposes lymphocytes, particularly CD4(+) T cells, CD8(-) T cells, and antigen-presenting cells, to evolve into effecters of apoptosis and as a result, to leadto the destruction of healthy, non-infected T cells. Tat and Nef, along with Vpu, can also protect HIV-infected cells from apoptosis by increasing anti-apoptotic proteins and down-regulating cell surface receptors recognizedby immune system cells. This review will discuss the validity of the apoptosis hypothesis in HIV disease and the potential mechanism(s) that HIV proteins perform in the progressive T cell depletion observed in AIDS pathogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:56:54