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Titolo:
Nontraumatic urethral dyssynergia in neonatally estrogenized male rats
Autore:
Streng, T; Launonen, A; Salmi, S; Saarinen, N; Talo, A; Makela, S; Santti, R;
Indirizzi:
Univ Turku, Inst Biomed, Dept Anat, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 , Dept Anat, FIN-20520 Turku, Finland Univ Turku, Dept Biol, Physiol Anim Lab, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 ol Anim Lab, FIN-20520 Turku, Finland Karolinska Inst, Dept Med Nutr, Unit Prevent Nutr, Huddinge, Sweden Karolinska Inst Huddinge Sweden tr, Unit Prevent Nutr, Huddinge, Sweden
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 4, volume: 165, anno: 2001,
pagine: 1305 - 1309
SICI:
0022-5347(200104)165:4<1305:NUDINE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLADDER OUTLET OBSTRUCTION; URINARY-BLADDER; ANESTHETIZED RATS; VOIDING CYCLE; RECEPTORS; SPHINCTER; ANDROGEN; TRACT;
Keywords:
diethylstilbestrol; urethra; rats; electromyography; urodynamics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Streng, T Univ Turku, Inst Biomed, Dept Anat, Kiinamyllynkatu 10, FIN-20520 Turku, Finland Univ Turku Kiinamyllynkatu 10 Turku Finland FIN-20520 , Finland
Citazione:
T. Streng et al., "Nontraumatic urethral dyssynergia in neonatally estrogenized male rats", J UROL, 165(4), 2001, pp. 1305-1309

Abstract

Purpose: Bladder outlet obstruction develops in estrogen treated males. Because of the lack of electromyography recordings, earlier studies have not clarified the failure mechanisms of voiding. We simultaneously recorded electromyography activity of the proximal rhabdosphincter in neonatally estrogenized rats with transvesical cystometry and urethral flow, followed by morphometric analysis of the urethral structure. Materials and Methods: Rats treated neonatally with 10 mug, diethylstilbestrol daily on days 1 to 5 after birth were used in urodynamics and morphological studies at ages 5 to 6.5 months. Using anesthesia the bladder, anterior surface of the proximal rhabdosphincter and distal urethra were exposed to record simultaneously the high frequency oscillations of intraluminal bladder pressure, and the rates of intermittent flow from the distal urethra and electromyography activity of the proximal rhabdosphincter with a suction electrode. Results: Neonatally estrogenized rats had higher mean maximal bladder pressure plus or minus standard deviation (42.1 +/- 6.4 versus 37.7 +/- 4.9 mm. Hg, p = 0.01), decreased mean flow (2.3 +/- 0.1 versus 4.1 +/- 1.6 mi. perminute, p < 0.0001) and mean increment of proximal rhabdosphincter electromyography depolarization amplitude (3.0 +/- 0.78 versus 2.6 +/- 0.87 mV., p= 0.02) compared with controls, while mean transient repolarization was absent or highly decreased (-0.3 +/- 0.61 versus 0.3 +/- 0.9 mV., p = 0.04). Morphologically the proximal rhabdosphincter was atrophied with increased connective tissue. Conclusions: Alterations in the structure and electromyography activity ofthe urethral musculature imply that neonatal exposure to diethylstilbestrol predisposes male rats to urethral atrophy and dyssynergia, evident as altered electromyography activity of the proximal rhabdosphincter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:25:55