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Titolo:
Intravenous clomipramine decreases excitability of human motor cortex. A study with paired magnetic stimulation
Autore:
Manganotti, P; Bortolomasi, M; Zanette, G; Pawelzik, T; Giacopuzzi, M; Fiaschi, A;
Indirizzi:
Univ Verona, Policlin GB Rossi, Sez Neurol, Sez Neurol Riabilitat, I-37100Verona, Italy Univ Verona Verona Italy I-37100 Neurol Riabilitat, I-37100Verona, Italy Casa Cura Villa S Chiara, Verona, Italy Casa Cura Villa S Chiara Verona Italy ura Villa S Chiara, Verona, Italy Policilin GB Rossi, Dipartimento Sci Neurol & Vis, Sez Neurol, Verona, Italy Policilin GB Rossi Verona Italy Neurol & Vis, Sez Neurol, Verona, Italy
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1, volume: 184, anno: 2001,
pagine: 27 - 32
SICI:
0022-510X(20010215)184:1<27:ICDEOH>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; BRAIN-STIMULATION; SILENT PERIOD; CORTICAL EXCITABILITY; INHIBITION; ANTIDEPRESSANTS; DEPRESSION; MEDICATION; POTENTIALS; RESPONSES;
Keywords:
transcranial magnetic stimulation; clomipramine; depression; treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Manganotti, P Univ Verona, Policlin Borgo Roma, Dipartimento Sci Neurol & Vis, Sez Neurol, Via Menegone, I-37134 Verona, Italy Univ Verona Via Menegone Verona Italy I-37134 Verona, Italy
Citazione:
P. Manganotti et al., "Intravenous clomipramine decreases excitability of human motor cortex. A study with paired magnetic stimulation", J NEUR SCI, 184(1), 2001, pp. 27-32

Abstract

Several recent reports suggest the possibility of monitoring pharmacological effects on brain excitability through transcranial magnetic stimulation (TMS). In these studies, paired magnetic stimulation has been used in normal subjects and on patients who were taking different antiepileptic drugs. The aim of our study was to investigate motor area excitability on depressedpatients after intravenous administration of a single dose of clomipramine, a tricyclic antidepressant. Motor cortex excitability was studied by single and paired transcranial magnetic stimulation (TMS) before and after 4, 8and 24 h from intravenous administration of 25 mg of clomipramine. Cortical excitability was measured using different TMS parameters: motor threshold(MT), motor evoked potential (MEP) amplitude, duration of cortical silent period (CSP), intracortical inhibition (ICI) and intracortical facilitation(ICF). Spinal excitability and peripheral nerve conduction was measured byF response and M wave. A temporary but significant increase of motor threshold and intracortical inhibition and a decrease of intracortical facilitation were observed 4 h following drug administration. MEP amplitude, cortical silent period, F response and M wave were not significantly affected by drug injection. Our findings suggest that a single intravenous dose of clomipramine can exert a significant but transitory suppression of motor cortex excitability in depressed patients. TMS represents a useful research tool in assessing the effects of motor cortical excitability of neuropsychiatric drugs used in psychiatric disease. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:32:34