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Titolo:
Dilated cardiomyopathy in isolated congenital complete atrioventricular block: Early and long-term risk in children
Autore:
ten Cate, FEAU; Breur, JMPJ; Cohen, MI; Boramanand, N; Kapusta, L; Crosson, JE; Brenner, JI; Lubbers, LJ; Friedman, AH; Vetter, VL; Meijboom, EJ;
Indirizzi:
Univ Med Ctr, Wilhelmina Childrens Hosp, Pediat Heart Ctr, NL-3508 AB Utrecht, Netherlands Univ Med Ctr Utrecht Netherlands NL-3508 AB 3508 AB Utrecht, Netherlands Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia Philadelphia PA USA 19104 lphia, PA 19104 USA Yale New Haven Hosp, New Haven, CT 06504 USA Yale New Haven Hosp New Haven CT USA 06504 Hosp, New Haven, CT 06504 USA Univ Med Ctr St Radboud, Nijmegen, Netherlands Univ Med Ctr St Radboud Nijmegen Netherlands oud, Nijmegen, Netherlands Johns Hopkins Hosp, Baltimore, MD 21287 USA Johns Hopkins Hosp Baltimore MD USA 21287 s Hosp, Baltimore, MD 21287 USA Amsterdam Med Ctr, Amsterdam, Netherlands Amsterdam Med Ctr Amsterdam Netherlands Med Ctr, Amsterdam, Netherlands
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 4, volume: 37, anno: 2001,
pagine: 1129 - 1134
SICI:
0735-1097(20010315)37:4<1129:DCIICC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLETE HEART-BLOCK; LEFT-VENTRICULAR MECHANICS; HYPERTROPHIC CARDIOMYOPATHY; CONGESTIVE CARDIOMYOPATHY; NATURAL-HISTORY; NEONATAL LUPUS; IMMUNOGLOBULIN; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Meijboom, EJ Univ Med Ctr, Wilhelmina Childrens Hosp, Pediat Heart Ctr, KG1-325-0,POB 85090, NL-3508 AB Utrecht, Netherlands Univ Med Ctr KG 1-325-0,POB 85090 Utrecht Netherlands NL-3508 AB
Citazione:
F.E.A.U. ten Cate et al., "Dilated cardiomyopathy in isolated congenital complete atrioventricular block: Early and long-term risk in children", J AM COL C, 37(4), 2001, pp. 1129-1134

Abstract

OBJECTIVES We sought to identify the risk factors predicting the development of dilated cardiomyopathy (DCM) in patients with isolated congenital complete atrioventricular block (CCAVB). BACKGROUND Recently evidence has emerged that a subset of patients with CCAVB develop DCM. METHODS This was a retrospective study of 149 patients with CCAVB who had heart size and left ventricular (LV) function assessed by echocardiography and chest radiograph! over a follow-up period of 10 +/- 7 years. RESULTS Nine patients developed DCM at the age of 6.5 +/- 5 fears. No definite cause could be identified. In these nine patients, CCAVB was diagnosedin eight at 23 +/- 2.3 weeks gestation and in one at birth. Maternal SSA/SSB antibodies were confirmed in seven of the nine patients. Pacemakers wereimplanted in eight patients in the first month and in one patient at five years of age. The initial left ventricular end-diastolic dimension (LVEDD) was in the 96th +/- 2.6 percentile and the cardiothoracic (CT) ratio was 64+/- 3.8% in the nine patients who developed DCM, and differed significantly in patients with CCAVB (p < 0.005) who did not develop DCM. The LVEDD andCT ratio did not decrease in the patients with CCAVB and DCM, but decreased significantly in the patients with CCAVB without DCM (p < 0.001) once pacing was initiated. Two patients with DCM died within two months of diagnosis; one patient is neurologically compromised; two patients received a hearttransplant; and four patients are listed for heart transplantation. CONCLUSIONS Isolated CCAVB is associated with a long-term risk for the development of DCM. Risk factors may be SSA/SSB antibodies, increased heart size at initial evaluation and the absence of pacemaker-associated improvement. (J Am Cell Cardiol 2001;37:1129-34) (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 00:10:37