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Titolo:
Up-regulation of inositol 1,4,5 trisphosphate receptor expression in atrial tissue in patients with chronic atrial fibrillation
Autore:
Yamada, J; Ohkusa, T; Nao, T; Yano, M; Kobayashi, S; Hamano, K; Esato, K; Matsuzaki, M;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Internal Med 2, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan Yamaguchi Univ, Sch Med, Dept Surg 1, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 4, volume: 37, anno: 2001,
pagine: 1111 - 1119
SICI:
0735-1097(20010315)37:4<1111:UOI1TR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC SARCOPLASMIC-RETICULUM; 1,4,5-TRISPHOSPHATE RECEPTOR; CA2+; LOCALIZATION; CHANNELS; MYOCYTES; CALCIUM; RELEASE; OSCILLATIONS; PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuzaki, M Yamaguchi Univ, Sch Med, Dept Internal Med 2, 1-1-1 Minami Kogushi, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ 1-1-1 Minami Kogushi Ube Yamaguchi Japan 7558505
Citazione:
J. Yamada et al., "Up-regulation of inositol 1,4,5 trisphosphate receptor expression in atrial tissue in patients with chronic atrial fibrillation", J AM COL C, 37(4), 2001, pp. 1111-1119

Abstract

OBJECTIVES We examined whether patients with atrial fibrillation (AF) havealterations in atrial inositol 1,4,5 trisphosphate receptors (IP3 receptors). BACKGROUND Abnormal intracellular Ca2+ homeostasis occurs in chronic AF. The intracellular Ca2+ concentration is regulated by ryanodine and IP3 receptors. We recently reported alterations in ryanodine receptors in atrial tissue from patients in chronic AF. METHODS We analyzed IP3 receptor expression in the right atrial myocardiumfrom 13 patients with mitral valvular disease (MVD) with AF (MVD/AF), fivepatients with MVD who had normal sinus rhythm (MVD/NSR) and eight control patients with NSR (tissue obtained during coronary artery bypass surgery). Hemodynamic and echocardiographic data were obtained preoperatively, and animmunohistochemical study was performed on atrial tissue. RESULTS The relative expression level of IP3 receptor protein was significantly greater in MVD/AF (0.75 +/- 0.26) than it was in MVD/NSR (0.42 +/- 0.13, p < 0.01), and both were significantly above control (0.14 <plus/minus>0.08). The relative expression level of IP3 receptor messenger RNA was significantly greater in the MVD/AF group (0.028 +/- 0.008) than it was in thecontrol group (0.015 +/- 0.003, p < 0.01), but patients with MVD/AF did not differ from patients with MVD/NSR (0.020 <plus/minus> 0.006). The relative expression levels of IP3 receptor protein and messenger RNA were higher in patients with left atrial dimension greater than or equal to 40 mm, pulmonary capillary wedge pressure greater than or equal to 10 mm Hg and right atrial pressure greater than or equal to5 mm Hg. Inositol 1,4,5 trisphosphate receptors were over-expressed in the cytosol and at the nuclear envelope of atrial myocytes in MVD. CONCLUSIONS Since chronic mechanical overload of the atrial myocardium increased IP3 receptor expression, especially ill patients with chronic AF, up-regulation of IP3 receptors may be important in modulating intracellular Ca2+ homeostasis and initiating or perpetuating AF. (J Am Coll Cardiol 2001;37:1111-9) (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 17:50:19