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Titolo:
Pulse pressure - A review of mechanisms and clinical relevance
Autore:
Dart, AM; Kingwell, BA;
Indirizzi:
Alfred Hosp, Alfred Baker Med Unit, Prahran, Vic 3181, Australia Alfred Hosp Prahran Vic Australia 3181 Unit, Prahran, Vic 3181, Australia Baker Med Res Inst, Melbourne, Vic, Australia Baker Med Res Inst Melbourne Vic Australia st, Melbourne, Vic, Australia
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 4, volume: 37, anno: 2001,
pagine: 975 - 984
SICI:
0735-1097(20010315)37:4<975:PP-ARO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATED SYSTOLIC HYPERTENSION; CONVERTING-ENZYME-INHIBITION; CORONARY-ARTERY DISEASE; DEPENDENT DIABETES-MELLITUS; BLOOD-PRESSURE; DOUBLE-BLIND; AORTIC DISTENSIBILITY; POSTMENOPAUSAL WOMEN; HEART-DISEASE; CARDIOVASCULAR MORTALITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
116
Recensione:
Indirizzi per estratti:
Indirizzo: Dart, AM Alfred Hosp, Alfred Baker Med Unit, Commercial Rd, Prahran, Vic 3181, Australia Alfred Hosp Commercial Rd Prahran Vic Australia 3181 1, Australia
Citazione:
A.M. Dart e B.A. Kingwell, "Pulse pressure - A review of mechanisms and clinical relevance", J AM COL C, 37(4), 2001, pp. 975-984

Abstract

The goal of this study was to review the origin, clinical relevance and treatment of pulse pressure (PP). Elevated PP is increasingly being recognized as a risk factor for cardiovascular, particularly coronary, disease. Pulse pressure is discussed in terms of both Windkessel and distributive modelsof the arterial circulation. Pulse pressure arises from the interaction ofcardiac ejection (stroke volume) and the properties of the arterial circulation. hn increased stiffness of the aorta and large arteries leads to an increase in PP through a reduction in arterial compliance and effects on wave reflection. A number of factors are known to influence arterial wall behavior and, therefore, PP. In addition to the effects of aging and blood pressure on arterial wall elasticity, there is some evidence that atherosclerosis, per se, amplifies these effects. Thus, the relationship between PP and coronary disease may be bidirectional. A number of dietary and lifestyle interventions have been shown to modify large artery behavior. These include aerobic exercise training and consumption of n-3 fatty acids. Conversely, strength training is associated with an increase in arterial stiffness and ahigher PP. The effects of antihypertensive medication have been extensively studied, but many studies are difficult to interpret because of concomitant change in blood pressure, and to a lesser degree, heart rate. However a number of studies do suggest direct arterial wall effects, particularly forangiotensin-converting enzyme inhibitors. A distributed compliance model of the arterial circulation provides a framework for understanding the causes, effects and potential treatment of elevations in PP. (J Am Coll Cardiol 2001;37:975-84) (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:09:55