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Titolo:
Effects of leuprolide acetate on adhesion formation and wound healing in the rat model
Autore:
Roberts, JE; Watkin, KL; Tulandi, T;
Indirizzi:
McGill Univ, Royal Victoria Hosp, Dept Obstet & Gynecol, Montreal, PQ H2X 2J5, Canada McGill Univ Montreal PQ Canada H2X 2J5 ecol, Montreal, PQ H2X 2J5, Canada Univ Illinois, Ultrasound Res Lab, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 ltrasound Res Lab, Urbana, IL 61801 USA
Titolo Testata:
JOURNAL OF THE AMERICAN ASSOCIATION OF GYNECOLOGIC LAPAROSCOPISTS
fascicolo: 1, volume: 8, anno: 2001,
pagine: 124 - 128
SICI:
1074-3804(200102)8:1<124:EOLAOA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE AGONIST TREATMENT; ENDOMETRIOSIS; PREVENTION; THERAPY; REFORMATION; SURGERY; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Roberts, JE McGill Univ, Royal Victoria Hosp, Dept Obstet & Gynecol, Womens Pavil,2058Jeanne Mance, Montreal, PQ H2X 2J5, Canada McGill Univ Womens Pavil,2058 Jeanne Mance Montreal PQ Canada H2X 2J5
Citazione:
J.E. Roberts et al., "Effects of leuprolide acetate on adhesion formation and wound healing in the rat model", J AM AS G L, 8(1), 2001, pp. 124-128

Abstract

Study Objective. To assess the effects of a hypoestrogenic state on adhesion formation and reformation and on wound healing in the rat model. Design. Prospective, randomized study (Canadian Task Force classification I). Subjects. Forty-eight female Sprague-Dawley rats. Interventions. Rats were injected with gonadotropin-hormone releasing hormone (GnRH) agonist and control rats with normal saline. Two weeks later (day zero) laparotomy was performed to create adhesions and a full-thickness wound on the flank. On day 14 the adhesions were scored and liberated. The rats were sacrificed on day 28 and adhesion reformation was evaluated. The wound surface area was measured serially until complete closure. Measurements and Main Results. Mean adhesion scores on day 14 after adhesion formation were not significantly different between GnRH agonist and control groups. Preadhesiolysis and postadhesiolysis scores were not significantly different. There was no significant difference in size of wounds between groups on days zero, 7, or 14. Conclusion. Administration of a GnRH agonist does not seem to influence postoperative adhesion formation or wound healing in the rat model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:33:50