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Titolo:
Effects of antipsychotic drugs on cytokine networks
Autore:
Pollmacher, T; Haack, M; Schuld, A; Kraus, T; Hinze-Selch, D;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany Univ Kiel, Dept Psychiat, Kiel, Germany Univ Kiel Kiel GermanyUniv Kiel, Dept Psychiat, Kiel, Germany
Titolo Testata:
JOURNAL OF PSYCHIATRIC RESEARCH
fascicolo: 6, volume: 34, anno: 2000,
pagine: 369 - 382
SICI:
0022-3956(200011/12)34:6<369:EOADOC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CLOZAPINE-INDUCED AGRANULOCYTOSIS; SOLUBLE INTERLEUKIN-2 RECEPTORS; TREATED SCHIZOPHRENIC-PATIENTS; DIFFERENT ETHNIC-GROUPS; PLASMA-LEVELS; NERVOUS-SYSTEM; CSF LEVELS; PHARMACOLOGICAL ACTIVITIES; RHEUMATOID-ARTHRITIS;
Keywords:
antipsychotic drugs; cytokine networks;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
137
Recensione:
Indirizzi per estratti:
Indirizzo: Pollmacher, T Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
T. Pollmacher et al., "Effects of antipsychotic drugs on cytokine networks", J PSYCH RES, 34(6), 2000, pp. 369-382

Abstract

It has been known since the 1950s that phenothiazines have immunomodulatory effects. This review summarizes recent evidence suggesting that antipsychotic drugs, in particular chlorpromazine and the atypical compound clozapine, influence the production of cytokines. Cytokines, organized in networks of related peptides with pleiotropic functions, are pivotal humoral mediators of infection and inflammation, and they play an important role in hematopoiesis and autoimmunity. Therefore, the effects of antipsychotic drugs on cytokine networks are important for the understanding of immune-mediated side effects of these drugs, e.g. agranulocytosis. In addition, modulation ofcytokine production by antipsychotic agents suggests that these drugs might be useful For the treatment of diseases which primarily involve the immune system. Moreover, because cytokines are known to have numerous effects onthe CNS. they may mediate effects of antipsychotic drugs on brain functions. Finally, the influence of antipsychotic drugs on cytokine networks is animportant confounding factor in studies investigating disease-related immunopathology in psychiatric disorders. This review provides a synopsis of the data published on these topics and outlines future research perspectives. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:17:03