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Titolo:
Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism
Autore:
Furlano, RI; Anthony, A; Day, R; Brown, A; McGarvey, L; Thomson, MA; Davies, SE; Berelowitz, M; Forbes, A; Wakefield, AJ; Walker-Smith, JA; Murch, SH;
Indirizzi:
Royal Free & Univ Coll Med Sch, Univ Dept Paediat Gastroenterol, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF n NW3 2PF, England Royal Free & Univ Coll Med Sch, Inflammatory Bowel Dis Study Grp, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF n NW3 2PF, England Royal Free & Univ Coll Med Sch, Univ Dept Med, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF n NW3 2PF, England Royal Free & Univ Coll Med Sch, Univ Dept Histopathol, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF n NW3 2PF, England Royal Free & Univ Coll Med Sch, Dept Child & Adolescent Psychiat, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF n NW3 2PF, England St Marks Hosp, IBD Res Unit, London EC1V 2PS, England St Marks Hosp London England EC1V 2PS Res Unit, London EC1V 2PS, England
Titolo Testata:
JOURNAL OF PEDIATRICS
fascicolo: 3, volume: 138, anno: 2001,
pagine: 366 - 372
SICI:
0022-3476(200103)138:3<366:CCAGDT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASSOCIATION; DISORDERS; AUTOANTIBODIES; COLITIS; MEASLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Murch, SH Royal Free & Univ Coll Med Sch, Univ Dept Paediat Gastroenterol,Royal Free Campus,Rowland Hill St, London NW3 2PF, England Royal Free & Univ Coll Med Sch Royal Free Campus,Rowland Hill St London England NW3 2PF
Citazione:
R.I. Furlano et al., "Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism", J PEDIAT, 138(3), 2001, pp. 366-372

Abstract

Objectives: We have reported colitis with ileal lymphoid nodular hyperplasia (LNH) in children with regressive autism. The aims of this study were tocharacterize this lesion and determine whether LNH is specific for autism. Methods: Ileo-colonoscopy was performed in 21 consecutively evaluated children with autistic spectrum disorders and bowel symptoms, Blinded comparison was made with 8 children with histologically normal ileum and colon, 10 developmentally normal children with ileal LNH, 15 with Crohn's disease, and14 with ulcerative colitis. Immunohistochemistry was performed for cell lineage and functional markers, and histochemistry was performed for glycosaminoglycans and basement membrane thickness,Results: Histology demonstrated lymphocytic colitis in the autistic children, less severe than classical inflammatory bowel disease. However, basement membrane thickness and mucosal gamma delta cell density were significantly increased above those of all other groups including patients with inflammatory bowel disease. CD8(+) density and intraepithelial lymphocyte numbers were higher than those in the Crohn's disease, LNH, and normal control groups; and CD3 and plasma cell density and crypt proliferation were higher than those in normal and LNH control groups. Epithelial, but not lamina propria, glycosaminoglycans were disrupted. However, the epithelium was HLA-DR-, suggesting a predominantly T(H)2 response. Interpretation: Immunohistochemistry confirms a distinct lymphocytic colitis in autistic spectrum disorders in which the epithelium appears particularly affected. This is consistent with increasing evidence for gut epithelial dysfunction in autism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:27:50