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Titolo:
Detection of IgA and IgC but not IgE antibody to respiratory syncytial virus in nasal washes and sera from infants with wheezing
Autore:
de Alarcon, A; Walsh, EE; Carper, HT; La Russa, JB; Evans, BA; Rakes, GP; Platts-Mills, TAE; Heymann, PW;
Indirizzi:
Univ Virginia Hlth Syst, Dept Pediat, Charlottesville, VA 22908 USA Univ Virginia Hlth Syst Charlottesville VA USA 22908 sville, VA 22908 USA Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 , Dept Med, Rochester, NY 14642 USA Univ Virginia Hlth Syst, Dept Hlth Evaluat Sci, Charlottesville, VA USA Univ Virginia Hlth Syst Charlottesville VA USA , Charlottesville, VA USA Univ Virginia Hlth Syst, Dept Internal Med, Charlottesville, VA USA Univ Virginia Hlth Syst Charlottesville VA USA , Charlottesville, VA USA
Titolo Testata:
JOURNAL OF PEDIATRICS
fascicolo: 3, volume: 138, anno: 2001,
pagine: 311 - 317
SICI:
0022-3476(200103)138:3<311:DOIAIB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NASOPHARYNGEAL SECRETIONS; INHALANT ALLERGENS; INFECTION; CHILDREN; ASTHMA; RESPONSES; BRONCHIOLITIS; CHILDHOOD; RISK; GLYCOPROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Heymann, PW Univ Virginia Hlth Syst, Dept Pediat, POB 800386, Charlottesville, VA 22908 USA Univ Virginia Hlth Syst POB 800386 Charlottesville VA USA22908
Citazione:
A. de Alarcon et al., "Detection of IgA and IgC but not IgE antibody to respiratory syncytial virus in nasal washes and sera from infants with wheezing", J PEDIAT, 138(3), 2001, pp. 311-317

Abstract

Background and Obiective: The capacity of respiratory syncytial virus (RSV) to stimulate an IgE antibody response and enhance the development of atopy and asthma remains controversial. Nasal washes and sera from 40 infants (20 with wheezing, 9 with rhinitis, and 11 without respiratory tract symptoms) were obtained to measure IgE. IgA, and IgG antibody to the immunodominant, F and G, virion proteins from RSV. Study design: Children (aged 6 weeks to 2 years) were enrolled in the emergency department during the mid-winter months and seen at follow-up when they were asymptomatic. All nasal washes were tested for RSV antigen. Determinations of antibody isotypes (IgE, IgA, and IgG) to RSV antigens were done in nasal washes and sera by using an enzyme-linked immunosorbent assay. In a subset of nasal washes, IgE to RSV was also evaluated by using a monoclonal anti-FcE antibody-based assay. Results: Fifteen patients with wheezing, two with rhinitis, and one control subject tested positive for RSV antigen at enrollment. Thirteen patients with wheezing were <6 months old, and most (77%) were experiencing their first attack. Among the children with positive test results for RSV antigen, an increase in both nasal wash and serum IgA antibody to RSV-F-a and G(a) was observed at the follow-up visit. However, there was no evidence for an IgE antibody response to either antigen. Conclusion: Both IgA and IgG antibodies to the immunodominant RSV-F-a and G(a) antigens were readily detected in the nasal washes and sera from patients in this study. We were unable to demonstrate specific IgE antibody to these antigens and conclude that the production of IgE as a manifestation ofa T(H)2 lymphocyte response to RSV is unlikely.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/06/20 alle ore 12:38:18