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Titolo:
Lipolytic effect of BRL 35 135, a beta 3 agonist, and its interaction withdietary lipids on the accumulation of fats in rat body
Autore:
Fotovati, A; Hayashi, T; Ito, T;
Indirizzi:
Kyushu Univ, Fac Agr, Lab Chem & Technol Anim Prod, Fukuoka, Japan Kyushu Univ Fukuoka Japan Lab Chem & Technol Anim Prod, Fukuoka, Japan
Titolo Testata:
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 153 - 161
SICI:
0955-2863(200103)12:3<153:LEOB31>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEEF TALLOW DIET; BROWN ADIPOSE-TISSUE; ADRENERGIC-RECEPTOR BINDING; BETA(3)-ADRENOCEPTOR AGONIST; BETA-3-ADRENERGIC RECEPTOR; ADIPOCYTES; ADRENOCEPTOR; OBESITY; NOREPINEPHRINE; BRL-35135;
Keywords:
beef tallow; beta-adrenoceptor agonists; BRL 35135; isoproterenol; lipolysis; vegetable oils;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Ito, T Kyushu Univ, Fac Agr, Lab Chem & Technol Anim Prod, Fukuoka, Japan Kyushu Univ Fukuoka Japan em & Technol Anim Prod, Fukuoka, Japan
Citazione:
A. Fotovati et al., "Lipolytic effect of BRL 35 135, a beta 3 agonist, and its interaction withdietary lipids on the accumulation of fats in rat body", J NUTR BIOC, 12(3), 2001, pp. 153-161

Abstract

The type of intaked fat and fat uptake mechanisms such as adrenergic-induced lipolysis affect patterns of fat accumulation in animal body. In this study, in vitro lipolytic effect of BRL 35135, a selective beta3 agonist, andits interaction with different dietary fats on fat accumulation in animal body (in vivo) were studied. For in vitro study, adipocytes isolated from epididymal fat were incubated with 10(-5) M-10(-9) M of either BRL 35135 or isoproterenol, a non-selective beta -agonist. In animal study, two groups of SD-rats, i.e., BRL35135-intaked (dosed at 0.5 mg/kg/day in diet) and control, were divided into 4 sub-groups and fed diets containing 12% of either beef tallow (BT), canola oil (CO), olive oil (OO) or safflower oil (SO) for6 weeks. In vitro study showed that BRL 35135 was 10 times more potent than isoproterenol in increasing the lipolysis in rat adipocytes. In animal study, inclusion of BRL35135 reduced daily weight gain in CO and SO groups (P< 0.05). Abdominal fat weight in BRL35135-intaked group was significantly lower than control in all dietary sub-groups (CO, OO and SO) except BT (P <0.05). In BT group, abdominal fat contained significantly higher amount oftotal saturated fatty acids (SFAs) compared to CO, OO or SO. It was concluded that, although BRL 35135 was very potent in increasing lipolysis in theisolated adipocytes of rat, its preventive effect on lipid accumulation inanimal body through the lipolysis could be affected by the type of dietaryfat and was lesser when rats fed fats rich in SFAs. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:33:43