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Titolo:
Changes in UCP mRNA expression levels in brown adipose tissue and skeletalmuscle after feeding a high-energy diet and relationships with leptin, glucose and PPAR gamma
Autore:
Margareto, J; Marti, A; Martinez, JA;
Indirizzi:
Univ Navarra, Dept Physiol & Nutr, Navarra 31008, Spain Univ Navarra Navarra Spain 31008 pt Physiol & Nutr, Navarra 31008, Spain
Titolo Testata:
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 130 - 137
SICI:
0955-2863(200103)12:3<130:CIUMEL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR AGONIST TREATMENT; UNCOUPLING PROTEIN-3 GENE; UP-REGULATION; DIFFERENTIAL REGULATION; THYROID-HORMONE; INDUCED OBESITY; RETINOIC ACID; MESSENGER-RNA; MICE; FAT;
Keywords:
uncoupling proteins; beta(3)-adrenergic receptor; peroxisome proliferator-activated receptor gamma 2; high-energy diet; skeletal muscle; brown adipose tissue;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Martinez, JA Univ Navarra, Dept Physiol & Nutr, Navarra 31008, Spain Univ Navarra Navarra Spain 31008 Nutr, Navarra 31008, Spain
Citazione:
J. Margareto et al., "Changes in UCP mRNA expression levels in brown adipose tissue and skeletalmuscle after feeding a high-energy diet and relationships with leptin, glucose and PPAR gamma", J NUTR BIOC, 12(3), 2001, pp. 130-137

Abstract

Brown adipose tissue and skeletal muscle are known to be important sites for nonshivering thermogenesis. In this context, it is accepted that uncoupling proteins (UCPs) are involved in such process, but little is known aboutthe physiological regulation of these proteins as affected by the intake of a high-energy (cafeteria) diet inducing fat deposition. In this study, the UCP messenger RNA (mRNA) expression in interscapular brown adipose tissue(iBAT) and skeletal muscle was assessed to evaluate the influence of a dietary manipulation on energy homeostasis regulation. We report a statistically significant increase in mRNA levels of iBAT UCP1 and UCP3 and a statistical marginal rise in skeletal muscle UCP3 mRNA expression after feeding a high-energy diet, whereas no changes in UCP2 expression were found in eithertissue. Furthermore, significant positive associations between iBAT UCP1 and UCP3 mRNA levels with serum leptin were found. Although the expression of the beta (3) adrenoceptor (beta (3)AR) was about 50% in the lean controlscompared with the obese group in iBAT, no statistically significant changes were observed concerning peroxisome proliferator-activated receptor gamma2 (PPAR gamma2) mRNA levels in muscle or iBAT. We conclude that feeding a diet inducing weight and fat gain produces different outcomes on iBAT and skeletal muscle UCP mRNA expression, revealing a tissue-dependent response for the three UCPs; Results suggest that the regulation of UCP expression in both tissues under these specific dietary conditions may be related to leptin circulating levels. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:51:22