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Titolo:
Acute and chronic effects of citalopram on postsynaptic 5-hydroxytryptamine(1A) receptor-mediated feedback: a microdialysis study in the amygdala
Autore:
Bosker, FJ; Cremers, TIFH; Jongsma, ME; Westerink, BHC; Wikstrom, VH; den Boer, JA;
Indirizzi:
Acad Hosp Groningen, Dept Psychiat, NL-9700 RB Groningen, Netherlands AcadHosp Groningen Groningen Netherlands NL-9700 RB ningen, Netherlands Univ Groningen, Ctr Pharm, Dept Med Chem, NL-9713 AW Groningen, Netherlands Univ Groningen Groningen Netherlands NL-9713 AW W Groningen, Netherlands
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 6, volume: 76, anno: 2001,
pagine: 1645 - 1653
SICI:
0022-3042(200103)76:6<1645:AACEOC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; 5-HT1A RECEPTORS; DOUBLE-BLIND; FRONTAL-CORTEX; EXTRACELLULAR 5-HYDROXYTRYPTAMINE; IN-VIVO; PHARMACOLOGICAL CHARACTERIZATION; DEPRESSED-PATIENTS; MAJOR DEPRESSION; INDUCED INCREASE;
Keywords:
amygdala; augmentation; citalopram; desensitization; feedback; 5-HT1A receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Bosker, FJ Acad Hosp Groningen, Dept Psychiat, Hanzeplein 1,POB 30-001, NL-9700 RB Groningen, Netherlands Acad Hosp Groningen Hanzeplein 1,POB 30-001Groningen Netherlands NL-9700 RB
Citazione:
F.J. Bosker et al., "Acute and chronic effects of citalopram on postsynaptic 5-hydroxytryptamine(1A) receptor-mediated feedback: a microdialysis study in the amygdala", J NEUROCHEM, 76(6), 2001, pp. 1645-1653

Abstract

Microdialysis was used to assess the involvement of postsynaptic 5-hydroxytryptamine(1A) (5-HT1A) receptors in the regulation of extracellular 5-HT in the amygdala. Local infusion of the 5-HT1A receptor agonist flesinoxan (0.3, 1, 3 muM) for 30 min into the amygdala maximally decreased 5-HT to 50% of basal level. Systemic administration of citalopram (10 mu mol/kg) increased 5-HT to 175% of basal revel. Local infusion of 1 muM of the 5-HT1A receptor antagonist WAY 100.635 into the amygdala augmented the effect of citalopram to more than 500% of basal 5-HT level. 5-HT1A receptor responsivenessafter chronic citalopram treatment was determined in two ways. First, by local infusion of 1 muM flesinoxan for 30 min into the amygdala, which showed a significant 63% reduction in response (area under the concentration-time curve; AUC) for the citalopram group compared to the saline group. Second, by systemic administration of citalopram (10 mu mol/kg), which increased 5-HT to 350% of basal level. The effect was larger than in untreated animals, but more important, local infusion of 1 muM WAY 100.635 into the amygdala now failed to augment the effect of citalopram. Both the flesinoxan and WAY 100.635 data suggest an involvement of postsynaptic 5-HT1A receptor-mediated feedback in the amygdala, which diminishes following chronic citalopram treatment.

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Documento generato il 25/01/20 alle ore 09:25:27