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Titolo:
Drosophila neuropeptide F mediates integration of chemosensory stimulationand conditioning of the nervous system by food
Autore:
Shen, P; Cai, HN;
Indirizzi:
Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 Dept Cellular Biol, Athens, GA 30602 USA
Titolo Testata:
JOURNAL OF NEUROBIOLOGY
fascicolo: 1, volume: 47, anno: 2001,
pagine: 16 - 25
SICI:
0022-3034(200104)47:1<16:DNFMIO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCAL PROTEIN-SYNTHESIS; Y RECEPTOR; PANCREATIC-POLYPEPTIDE; MOLECULAR-CLONING; MEMORY STORAGE; TASTE BEHAVIOR; PEPTIDE-YY; SYNAPSES; APLYSIA; HOMOLOG;
Keywords:
neuropeptide F; NPY homolog; gustation; activity-dependent neural modification; food response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Shen, P Univ Georgia, Dept Cellular Biol, 724 Biol Sci Bldg, Athens, GA 30602 USA Univ Georgia 724 Biol Sci Bldg Athens GA USA 30602 s, GA 30602 USA
Citazione:
P. Shen e H.N. Cai, "Drosophila neuropeptide F mediates integration of chemosensory stimulationand conditioning of the nervous system by food", J NEUROBIOL, 47(1), 2001, pp. 16-25

Abstract

The conserved neuropeptide Y (NPY) signaling pathway has been strongly implicated in the stimulation of food uptake in vertebrates as well as in the regulation of food conditioned foraging behaviors of Caenorhabditis elegans. Using in situ RNA hybridization and immunocytochemistry, we report the neuronal network of Drosophila neuropeptide F (dNPF), a human NPY homologue, in the larval central nervous system and its food-dependent modifications. We provide indications that gustatory stimulation by sugar, but not its ingestion or metabolism, is sufficient to trigger long-term, dose-dependent alterations of the dNPF neuronal circuit through both dnpf activation and increased synaptic transmission. Our results strongly suggest that the dNPF neuronal circuit is an integral part of the sensory system that mediates foodsignaling, providing the neural basis for understanding how invertebrate NPY regulates food response, (C) 2001 John Wiley Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:33:50