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Titolo:
Fatty acids inhibit leptin signalling in BRIN-BD11 insulinoma cells
Autore:
Briscoe, CP; Hanif, S; Arch, JRS; Tadayyon, M;
Indirizzi:
SmithKline Beecham Pharmaceut, Dept Vasc Biol, Harlow CM19 5AD, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AD ssex, England Univ Glasgow, Div Biochem & Mol Biol, Glasgow G12 8QQ, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G12 8QQ ow G12 8QQ, Lanark, Scotland
Titolo Testata:
JOURNAL OF MOLECULAR ENDOCRINOLOGY
fascicolo: 2, volume: 26, anno: 2001,
pagine: 145 - 154
SICI:
0952-5041(200104)26:2<145:FAILSI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC BETA-CELLS; DIABETIC MICE; OB RECEPTOR; DB/DB MICE; OBESE GENE; OB/OB MICE; IN-VIVO; ISLETS; ACTIVATION; SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Tadayyon, M SmithKline Beecham Pharmaceut, Dept Vasc Biol, New Frontiers Sci Pk, Harlow CM19 5AD, Essex, England SmithKline Beecham Pharmaceut New Frontiers Sci Pk Harlow Essex England CM19 5AD
Citazione:
C.P. Briscoe et al., "Fatty acids inhibit leptin signalling in BRIN-BD11 insulinoma cells", J MOL ENDOC, 26(2), 2001, pp. 145-154

Abstract

The effect of treatment with a 0.03% fatty acid (FA) cocktail on leptin-receptor-mediated STAT (signal transducers and activators of transcription) activation in the rat insulinoma cell line BRIN-BD11 was investigated. Leptin (10 nM) stimulated the tyrosine phosphorylation of STAT3 and STAT5b. Acute treatment with FAs prevented leptin-stimulated STAT3 tyrosine phosphorylation and significantly raised basal STAT5 phosphorylation. A chronic treatment (5 days) of BRIN-BD11 cells with FAs similarly attenuated leptin-stimulated STAT tyrosine phosphorylation. Chronic FA treatment also attenuated prolactin-stimulated STAT5b tyrosine phosphorylation but not interleukin-6-stimulated STAT3 tyrosine phosphorylation, suggesting that the effect is receptor/ligand specific. TaqMan analysis of gene expression following chronic FA treatment showed neither a decrease in the amount of leptin receptor (Ob-R) mRNA, nor an increase in the negative regulators of STAT signalling, SOCS3 (suppressors of cytokine signalling) or cytokine inducible sequence (CIS). These data demonstrate that FAs modulate leptin and prolactin signalling in beta -cells, implying that high levels of circulating FAs present in obese individuals affect the action of selective cytokines in P-cell function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:18:33