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Titolo:
Leptin: a potential regulator of polymorphonuclear neutrophil bactericidalaction?
Autore:
Caldefie-Chezet, F; Poulin, A; Tridon, A; Sion, B; Wasson, MP;
Indirizzi:
Fac Pharm Clermont Ferrand, Lab Biochim Biol Mol & Nutr, Ctr Rech Nutr Humaine, F-63001 Clermont Ferrand 1, France Fac Pharm Clermont Ferrand Clermont Ferrand France 1 t Ferrand 1, France Fac Pharm Clermont Ferrand, Immunol Lab, F-63001 Clermont Ferrand, France Fac Pharm Clermont Ferrand Clermont Ferrand France F-63001 rrand, France Fac Pharm Clermont Ferrand, Dev Biol Lab, F-63001 Clermont Ferrand 1, France Fac Pharm Clermont Ferrand Clermont Ferrand France 1 t Ferrand 1, France
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 3, volume: 69, anno: 2001,
pagine: 414 - 418
SICI:
0741-5400(200103)69:3<414:LAPROP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-RESPONSE; FOOD-INTAKE; OBESE GENE; TISSUES; CELLS; BRAIN;
Keywords:
receptor; reactive oxygen species; bactericide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Caldefie-Chezet, F Fac Pharm Clermont Ferrand, Lab Biochim Biol Mol & Nutr, Ctr Rech Nutr Humaine, EA 2416,28 Pl Henri Dunant,BP 38, F-63001 ClermontFerrand 1, France Fac Pharm Clermont Ferrand EA 2416,28 Pl Henri Dunant,BP38 Clermont Ferrand France 1
Citazione:
F. Caldefie-Chezet et al., "Leptin: a potential regulator of polymorphonuclear neutrophil bactericidalaction?", J LEUK BIOL, 69(3), 2001, pp. 414-418

Abstract

It is well known that leptin, the ob gene product, is involved in the regulation of food intake and thermogenesis. Recent studies also demonstrate that leptin may be able to modulate functions of cells involved in nonspecific immune response such as phagocytosis and secretion of cytokines by macrophages. This and the prominent implication of polymorphonuclear neutrophils (PMNs) in infectious response suggested a possible role of leptin as a modulator of PMN functions. We detected a leptin receptor on the PMN membrane by immunocytochemistry with an anti-leptin receptor, Using chemiluminescencewe then demonstrated that leptin enhances oxidative species production by stimulated PMNs. These results show for the first time that a functional leptin receptor is present on PMNs and that leptin may be able to influence their oxidative capacity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:29:28