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Titolo:
Fetal cells in transcervical samples at an early stage of gestation
Autore:
Adinolfi, M; Sherlock, J;
Indirizzi:
Univ Coll London, Galton Lab, London NW1 2HE, England Univ Coll London London England NW1 2HE ton Lab, London NW1 2HE, England Univ Coll London, Dept Obstet & Gynaecol, London NW1 2HE, England Univ Coll London London England NW1 2HE ynaecol, London NW1 2HE, England
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 3, volume: 46, anno: 2001,
pagine: 99 - 104
SICI:
1434-5161(2001)46:3<99:FCITSA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRENATAL-DIAGNOSIS; FIRST-TRIMESTER; TROPHOBLAST CELLS; UTERINE CAVITY; HB MUTATIONS; LAVAGE; ANEUPLOIDIES; CHROMOSOME; SEQUENCES; PREGNANCY;
Keywords:
fetal cells; non invasive prenatal diagnosis; transcervical cells; small tandem repeats (STRs); quantitative fluorescent PCR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Adinolfi, M Univ Coll London, Galton Lab, 4 Stephenson Way, London NW1 2HE, England Univ Coll London 4 Stephenson Way London England NW1 2HE land
Citazione:
M. Adinolfi e J. Sherlock, "Fetal cells in transcervical samples at an early stage of gestation", J HUM GENET, 46(3), 2001, pp. 99-104

Abstract

Several investigations are in progress with the aim of performing prenataldiagnosis of inherited disorders by noninvasive or minimally invasive techniques. The most important approaches are based on the detection of fetal nucleated cells in maternal blood, the analysis of fetal DNA present in maternal plasma, and the identification and isolation of fetal trophoblastic cellular elements shed into the uterine cavity and the endocervical canal. Inthis review, we discuss the methods that have been employed for the collection of the transcervical samples at an early stage of gestation and the techniques used for the identification of fetal cells. We also report the results of using endocervical cells for the detection of fetal chromosomal disorders by fluorescent in-situ hybridization and for performing prenatal diagnosis of fetal Rh(D) phenotypes. Recent investigations have also shown that - after the isolation of trophoblastic cells from maternal contaminants by micromanipulation - transcervical samples can be employed for the prenatal diagnosis of single gene defects, such as those causing thalassemia and sickle cell anemia. Although the present results are promising, further investigations are required to demonstrate the feasibility of performing accurate diagnosis of fetal diseases by this minimally invasive approach in all transcervical samples retrieved at an early stage of gestation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:41:09