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Titolo:
Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis
Autore:
Honda, K; Nakano, H; Yoshida, H; Nishikawa, S; Rennert, P; Ikuta, K; Tamechika, M; Yamaguchi, K; Fukumoto, T; Chiba, T; Nishikawa, SI;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Mol Genet, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Mol Genet, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Dept Gastroenterol, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Dept Gastroenterol, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Dept Med Chem, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Med, Dept Med Chem, Kyoto 6068507, Japan Juntendo Univ, Sch Med, Dept Immunol, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 ed, Dept Immunol, Tokyo 1138421, Japan Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Tokyo 1010062, Japan Japan Sci & Technol Corp Tokyo Japan 1010062 chnol, Tokyo 1010062, Japan Biogen Inc, Dept Immunol, Cambridge, MA 02142 USA Biogen Inc Cambridge MAUSA 02142 , Dept Immunol, Cambridge, MA 02142 USA Yamaguchi Univ, Sch Med, Inst Lab Anim, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan Yamaguchi Univ, Sch Med, Dept Anat, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 5, volume: 193, anno: 2001,
pagine: 621 - 630
SICI:
0022-1007(20010305)193:5<621:MBFHID>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL LYMPHOID ORGANS; LYMPHOTOXIN-BETA-RECEPTOR; TUMOR-NECROSIS-FACTOR; B-CELL; DEFICIENT MICE; INTERLEUKIN-7 RECEPTOR; STROMAL CELLS; T-CELLS; EXPRESSION; ALPHA;
Keywords:
lymphoid tissue; lymphotoxin; interleukin 7; chemokines; chemotaxis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Honda, K Kyoto Univ, Grad Sch Med, Dept Mol Genet, Sakyo Ku, Syogoin Kawaharacho 53, Kyoto 6068507, Japan Kyoto Univ Syogoin Kawaharacho 53 Kyoto Japan 6068507 507, Japan
Citazione:
K. Honda et al., "Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis", J EXP MED, 193(5), 2001, pp. 621-630

Abstract

Mice deficient in lymphotoxin beta receptor (LT betaR) or interleukin 7 receptor alpha (IL-7R alpha) lack Peyer's patches (PPs). Deficiency in CXC chemokine receptor 5 (CXCR5) also severely affects the development of PPs. A molecular network involving these three signaling pathways has been implicated in PP organogenesis, but it remains unclear how they are connected during this process. We have shown that PP organogenesis is initiated at sites containing IL-7R alpha (+):lymphoid cells and vascular cell adhesion molecule (VCAM)-1/intercellular adhesion molecule (ICAM)-1 expressing nonlymphoidelements. Here we characterize these lymphoid and nonlymphoid components in terms of chemokine signals. The lymphoid population expresses CXCR5 and has a strong chemotactic response to B lymphocyte chemoattractant (BLC). Importantly, chemokines produced by VCAM-1(+)ICAM-1(+) nonlymphoid cells mediate the recruitment of lymphoid cells. Furthermore, we show that these VCAM-1(+)ICAM-1(+) cells are mesenchymal cells that are activated by lymphoid cells through the I;TPR to express adhesion molecules and chemokines. Thus, promotion of PP development relies on mutual interaction between mesenchymaland lymphoid cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:53:16