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Titolo:
Water metabolism disturbances at different stages of primary thyroid failure
Autore:
Sahun, M; Villabona, C; Rosel, P; Navarro, MA; Ramon, JM; Gomez, JM; Soler, J;
Indirizzi:
Ciutat Sanitaria & Univ Bellvitge, Hosp Princeps Espanya, Dept Prevent Med, Barcelona, Spain Ciutat Sanitaria & Univ Bellvitge Barcelona Spain Med, Barcelona, Spain Ciutat Sanitaria & Univ Bellvitge, Hosp Princeps Espanya, Hormone Unit, Barcelona, Spain Ciutat Sanitaria & Univ Bellvitge Barcelona Spain nit, Barcelona, Spain Ciutat Sanitaria & Univ Bellvitge, Hosp Princeps Espanya, Dept Endocrinol,Barcelona, Spain Ciutat Sanitaria & Univ Bellvitge Barcelona Spain inol,Barcelona, Spain
Titolo Testata:
JOURNAL OF ENDOCRINOLOGY
fascicolo: 3, volume: 168, anno: 2001,
pagine: 435 - 445
SICI:
0022-0795(200103)168:3<435:WMDADS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL NATRIURETIC PEPTIDES; ARGININE-VASOPRESSIN; PRIMARY HYPOTHYROIDISM; EXCRETION; HYPERTHYROIDISM; OSMOREGULATION; MYXEDEMA; DISEASE; RATS; SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Sahun, M Bonsoms 29-33 4 1a Esc A, Barcelona 08028, Spain Bonsoms 29-33 41a Esc A Barcelona Spain 08028 ona 08028, Spain
Citazione:
M. Sahun et al., "Water metabolism disturbances at different stages of primary thyroid failure", J ENDOCR, 168(3), 2001, pp. 435-445

Abstract

The aim of the present study was to study salt and water metabolism in thyroid deficiency. We performed an oral water loading test (OWL) and a hypertonic 5% saline infusion test (HSI) in 16 patients with overt primary hypothyroidism before replacement treatment (PRE group) and after, in eight patients with subclinical hypothyroidism (SUB group) and in 16 normal individuals (CG group). In the PRE group, a lower free water clearance was detected in the OWL (P<0.022), with lower plasma osmolality (OWL: P<0.005; HSI: P<0.001) and arginine vasopressin (AVP) (OWL: P<0.001; HSI: P<0.001) than the CG group, across both tests; they normalized with the replacement treatment. The same plasma abnormalities were detected in the SUB group with the HSI. Although the AVP and thirst thresholds did not differ between the groups, the lag between them was lower in the PRE (4.1 <plus/minus> 3.2 mOsm/kg) and SUB group (2.6 +/- 2.1 mOsm/kg)than in the CG group (13.3 +/- 9.2 mOsm/kg) (P<0.05). There were no differences in atrial natriuretic hormone (ANH), plasma renin activity (PRA) and plasma aldosterone among the groups. These results indicate that plasma hypo-osmolality and low levels of AVP are present in primary hypothyroidism, and indeed are already present in thesubclinical phase of the disease. An overlap between the thresholds of thirst and AVP seem to play a role in these abnormalities, but ANH, PRA and plasma aldosterone do not appear to contribute.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:25:17