Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The effects of ECT on brain glucose: A pilot FDG PET study
Autore:
Henry, ME; Schmidt, ME; Matochik, JA; Stoddard, EP; Potter, WZ;
Indirizzi:
McLean Hosp, Belmont, MA 02178 USA McLean Hosp Belmont MA USA 02178McLean Hosp, Belmont, MA 02178 USA Harvard Univ, Sch Med, Dept Psychiat, Cambridge, MA 02138 USA Harvard Univ Cambridge MA USA 02138 ept Psychiat, Cambridge, MA 02138 USA Lilly Res Labs, Indianapolis, IN USA Lilly Res Labs Indianapolis IN USALilly Res Labs, Indianapolis, IN USA Natl Inst Drug Abuse, Brain Imaging Ctr, Baltimore, MD 21224 USA Natl InstDrug Abuse Baltimore MD USA 21224 Ctr, Baltimore, MD 21224 USA
Titolo Testata:
JOURNAL OF ECT
fascicolo: 1, volume: 17, anno: 2001,
pagine: 33 - 40
SICI:
1095-0680(200103)17:1<33:TEOEOB>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; ELECTROCONVULSIVE-THERAPY; MOOD DISORDERS; SUBCORTICAL LESIONS; FUTURE-RESEARCH; METABOLIC-RATE; DEPRESSION; BLOCKADE; IDAZOXAN;
Keywords:
electroconvulsive therapy; brain glucose; [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Henry, ME McLean Hosp, Adm Bldg,Rm G21,115 Mill St, Belmont, MA 02178 USA McLean Hosp Adm Bldg,Rm G21,115 Mill St Belmont MA USA 02178 USA
Citazione:
M.E. Henry et al., "The effects of ECT on brain glucose: A pilot FDG PET study", J ECT, 17(1), 2001, pp. 33-40

Abstract

Background: Regional brain activity was measured before and after electroconvulsive therapy (ECT) using [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET). Methods: 6 patients (4 females) with major depression were free of psychotropic medications for at least 2 weeks prior to baseline FDG scans. Patients were treated with bifrontotemporal ECT, and posttreatment scans were obtained after the last treatment. Results: A region of interest (ROI) analysis of absolute metabolic rate showed a decrease in CMRgluafter ECT in all 61 regions examined. In 17 of the 61 regions, the decrease was significant at the p < 0.05 level. In the right parietal lobe, and the right anterior and left posterior frontal lobes, the decrease in CMRglu significantly correlated with the decrease in Hamilton Depression Rating Scale (HDRS) scores (r = 0.83, 0.82, and 0.84, respectively). The analysis of CMRglu normalized to global metabolic rate showed significant increases in 8 of 61 regions, including basal ganglia, upper brainstem, and occipital lobe. Discussion: The decreases in global glucose metabolism and correlation of changes in frontal metabolism with decreases in HDRS are consistent withearlier brain imaging studies of ECT. The relative increases in CMRglu observed in regions with known dopaminergic innervation (caudate and upper brainstem) have not been previously reported.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:12:18