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Titolo:
ECS-induced mossy fiber sprouting and BDNF expression are attenuated by ketamine pretreatment
Autore:
Chen, ACH; Shin, KH; Duman, RS; Sanacora, G;
Indirizzi:
Yale Univ, Sch Med, Abraham Ribicoff Res Facil, Connecticut Mental Hlth Ctr, New Haven, CT 06508 USA Yale Univ New Haven CT USA 06508 Mental Hlth Ctr, New Haven, CT 06508 USA
Titolo Testata:
JOURNAL OF ECT
fascicolo: 1, volume: 17, anno: 2001,
pagine: 27 - 32
SICI:
1095-0680(200103)17:1<27:EMFSAB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC ELECTROCONVULSIVE SEIZURES; DENTATE GYRUS; MESSENGER-RNA; RAT-BRAIN; SYNAPTIC REORGANIZATION; NEUROTROPHIC FACTOR; MAJOR DEPRESSION; STRESS; HIPPOCAMPUS; NEURONS;
Keywords:
seizure; N-methyl-D-aspartate (NMDA); ketamine; electroconvulsive therapy; brain-derived neurotrophic factor; sprouting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Sanacora, G Yale Univ, Sch Med, Abraham Ribicoff Res Facil, Connecticut Mental Hlth Ctr, 34 Pk St, New Haven, CT 06508 USA Yale Univ 34 Pk St New Haven CT USA 06508 Haven, CT 06508 USA
Citazione:
A.C.H. Chen et al., "ECS-induced mossy fiber sprouting and BDNF expression are attenuated by ketamine pretreatment", J ECT, 17(1), 2001, pp. 27-32

Abstract

Recent evidence suggests hippocampal and possibly cortical atrophy is associated with major depression. Chronic electroconvulsive seizures (ECS) induce brain-derived neurotrophic factor (BDNF) expression and sprouting of themossy fiber pathway in the hippocampus, effects that may be related to electroconvulsive therapy's (ECT) mechanism of action. The objective of this study was to investigate the role of NMDA (N-methyl-D-aspartate) receptor inmediating the ECS-induced mossy fiber sprouting and BDNF expression. Timm histochemistry and in situ hybridization methodologies were used to determine the effect of pretreatment with ketamine, an NMDA antagonist, on ECS-induced sprouting and BDNF expression. The results demonstrate the ability of ketamine pretreatment to attenuate ECS-induced sprouting in the dentate gyrus and BDNF expression in the medial prefrontal cortex and the dentate gyrus. In addition, we found a significant decrease in seizure duration with ketamine pretreatment. These data suggest that NMDA receptor activation contributes to both the regulation of neurotrophic factor expression and the morphological changes associated with seizure activity. However, other effectsresulting from shortened seizure duration and seizure intensity cannot be excluded. These findings are of increasing interest, as they relate to the use of ECT in the treatment of depression, and the specific anesthetic agents that are used.

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Documento generato il 27/01/20 alle ore 02:20:49