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Titolo:
Changes in quantitatively assessed tremor during treatment of major depression with lithium augmented by paroxetine or amitriptyline
Autore:
Zaninelli, R; Bauer, M; Jobert, M; Muller-Oerlinghausen, B;
Indirizzi:
SmithKline Beecham Pharmaceut, Clin Dev CNS GI, Philadelphia, PA USA SmithKline Beecham Pharmaceut Philadelphia PA USA , Philadelphia, PA USA Free Univ Berlin, Dept Psychiat, Berlin Lithium Clin, D-1000 Berlin, Germany Free Univ Berlin Berlin Germany D-1000 hium Clin, D-1000 Berlin, Germany PAREXEL Int, Biosignaling Proc Div, Berlin, Germany PAREXEL Int Berlin Germany Int, Biosignaling Proc Div, Berlin, Germany
Titolo Testata:
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 21, anno: 2001,
pagine: 190 - 198
SICI:
0271-0749(200104)21:2<190:CIQATD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT1A RECEPTOR FUNCTION; DOUBLE-BLIND; ANTIDEPRESSANT TREATMENT; SEROTONERGIC FUNCTION; FLUOXETINE; TOLERABILITY; COMBINATION; CITALOPRAM; MECHANISMS; MEDICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Zaninelli, R GlaxoSmithKline, Clin Res & Dev, Collegeville, PA 19428 USA GlaxoSmithKline Collegeville PA USA 19428 ille, PA 19428 USA
Citazione:
R. Zaninelli et al., "Changes in quantitatively assessed tremor during treatment of major depression with lithium augmented by paroxetine or amitriptyline", J CL PSYCH, 21(2), 2001, pp. 190-198

Abstract

Tremor is a relatively frequent side effect of Lithium and of antidepressants with serotonergic properties. It can be expected that combinations of Lithium (which is itself serotonergic) with such antidepressants will enhance not only efficacy, but also the incidence of side effects, including tremor. To quantitatively monitor the effect of antidepressant augmentation of ongoing lithium therapy on tremor, Lithium-maintained patients with a breakthrough episode of major depression were randomly assigned under double-blind conditions to receive paroxetine 20 mg/day (N = 14) or amitriptyline 75 mg/day (N = 17). The initial dosages could be increased after 2 weeks to 40mg/day and 150 mg/day, respectively, and the patients were treated for 6 weeks. Tremor activity was assessed weekly, quantitatively by accelerometry and qualitatively with the Dosage Record and Treatment Emergent Symptom Scale. Statistical analysis detected no significant difference between the treatment groups with respect to changes in mean tremor activity relative to baseline. However, analysis of the pooled data showed that tremor increased significantly during the course of combined Lithium and antidepressant therapy, with the greatest increments occurring independent of dosage approximately 3 weeks after initiation of combination treatment. Although the mean tremor activity subsided toward the end of treatment, tremor activity on thewhole was still significantly greater after 6 weeks of combined Lithium and antidepressant treatment than at the start of combination therapy. Increased tremor was not associated with decreased medication compliance, and no patient discontinued treatment because of increased tremor. Tremor frequency was not affected by the study treatments.

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Documento generato il 06/04/20 alle ore 01:58:11