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Titolo:
Estrogen receptor beta, but not estrogen receptor alpha, is present in thevascular endothelium of the human and nonhuman primate endometrium
Autore:
Critchley, HOD; Brenner, RM; Henderson, TA; Williams, K; Nayak, NR; Slayden, OD; Millar, MR; Saunders, PTK;
Indirizzi:
Univ Edinburgh, Ctr Reprod Biol, Dept Obstet & Gynecol, Edinburgh EH3 9ET,Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH3 9ET Midlothian, Scotland MRC, Human Reprod Sci Unit, Ctr Reprod Biol, Edinburgh EH3 9ET, Midlothian, Scotland MRC Edinburgh Midlothian Scotland EH3 9ET h EH3 9ET, Midlothian, Scotland Oregon Reg Primate Res Ctr, Beaverton, OR 97006 USA Oregon Reg Primate ResCtr Beaverton OR USA 97006 Beaverton, OR 97006 USA
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 3, volume: 86, anno: 2001,
pagine: 1370 - 1378
SICI:
0021-972X(200103)86:3<1370:ERBBNE>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGESTERONE-RECEPTOR; ER-BETA; MENSTRUAL-CYCLE; CHROMOSOMAL LOCALIZATION; REPRODUCTIVE-TRACT; ANTIGEN RETRIEVAL; ANDROGEN RECEPTOR; INJURY RESPONSE; MESSENGER-RNA; GROWTH-FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Critchley, HOD Univ Edinburgh, Ctr Reprod Biol, Dept Obstet & Gynecol, 37 Chalmers St, Edinburgh EH3 9ET, Midlothian, Scotland Univ Edinburgh 37 Chalmers St Edinburgh Midlothian Scotland EH3 9ET
Citazione:
H.O.D. Critchley et al., "Estrogen receptor beta, but not estrogen receptor alpha, is present in thevascular endothelium of the human and nonhuman primate endometrium", J CLIN END, 86(3), 2001, pp. 1370-1378

Abstract

Estrogen action is dependent upon the presence of specific ligand-activated receptors in target tissues. The aim of the present experiments was to compare the spatial and temporal pattern of expression of estrogen receptor beta (ER beta) with that of ER alpha in full thickness endometrial samples (from the superficial to the basal zone) obtained from both women and rhesusmacaques. Immunohistochemical localization with specific antibodies revealed that ER alpha and ER beta were both expressed in nuclei of the glands and stroma. Consistent with previous studies, expression of ER alpha declinedin the glands and stroma of the functionalis during the secretory phase. The luminal epithelium also displayed positive immunoreactivity for ER beta. Expression of ER beta declined in glandular cell nuclei, but not stroma, within the functionalis during the late secretory phase. Levels of expression of ER alpha and ER beta in all cellular compartments remained unchanged in the basalis. Both receptor subtypes were detected on Western blots using proteins extracted from uterine samples obtained throughout the menstrual cycle. There was a striking contrast between the pattern of expression of ER alpha and ER beta in the vascular endothelium and the perivascular cells surrounding endometrial blood vessels; only ER beta was present in the endothelial cell population, although bath forms of ER were expressed in perivascularcells. We conclude that estrogen action(s) within the vascular endotheliumin the endometrium may be mediated via direct binding to the ER beta isoform and that these cells could therefore be a target for agonists or antagonists that selectively target the beta form of the ER.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 17:16:29